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Table 1 Cox regression analysis of RFS based on manual and automated assessment of HMG-CoAR expression.

From: Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer

 

Manual Analysis

Autoscore Continuous

Autoscore Dichotomised

 

HR (95%CI)

P value

HR (95%CI)

P value

HR (95%CI)

P value

 

Univariate

 

Univariate

 

Univariate

 

HMG-CoAR

(high versus low)

0.52 (0.30-0.91)

0.022

0.98 (0.97 -- 0.99)

0.039

0.47 (0.25 -- 0.87)

0.017

Stage

(continuous)

2.17 (1.16-4.03)

0.015

2.17 (1.16 - 4.03)

0.015

2.17 (1.16 - 4.03)

0.015

Grade

(Low versus moderate and high)

1.32 (0.62-2.81)

0.471

1.32 (0.62 - 2.81)

0.471

1.32 (0.62 - 2.81)

0.471

Resdiual Disease

(no macrscopic disease v's macroscopic disease)

0.79 (0.35-1.81)

0.58

0.79 (0.35 - 1.81)

0.58

0.79 (0.35 - 1.81)

0.58

 

Multivariate*

 

Multivariate*

 

Multivariate*

 

HMG-CoAR

(high versus low)

0.52 (0.30-0.96)

0.036

0.99 (0.97 -- 0.99)

0.04

0.49 (0.25 -- 0.99)

0.03

Stage

(continuous)

1.31 (0.61-2.80)

0.485

1.33 (0.64-2.77)

0.447

1.40 (0.66 - 2.95)

0.373

Grade

(Low versus moderate and high)

2.03 (0.66-6.27)

0.216

1.15 (0.43-3.07)

0.777

1.28 (0.49 - 3.29)

0.61

Resdiual Disease

(no macrscopic disease v's macroscopic disease)

0.40 (0.12 1.29)

0.123

0.87 (0.53 - 1.45)

0.597

0.88 (0.53 - 1.50)

0.621