Figure 3
From: 5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice
The hydrogel system delayed release and increased uptake of methylene blue. Mice were intraperitoneally injected methylene blue-hydrogel and then sacrificed at 2 h, 8 h, 24 h, 48 and 72 h to observe the release and increased uptake of methylene blue. The hydrogelization of methylene blue resulted in delayed release and increased uptake until 48 h (white short arrows), while methylene blue alone were discharged at about 8 h. The delayed release of methylene blue also observed in bladder (black long arrows).