Table 4 Neurologic adverse reactions of thalidomide and bortezomib in relation to phenotype in CYP2C19 C and CYP2D6
Parameter | CYP2C19 EM (%) | CYP2C19 IM + PM (%) | P value | CYP2D6 UM + EM (%) | CYP2D6 IM + PM (%) | p value |
|---|---|---|---|---|---|---|
Thalidomide | ||||||
Grade 0 + 1 | 64 (51) | 21 (52) | 0.6 | NR | NR | 0.7 |
Grade 2 | 36 (29) | 5 (13) | ||||
Grade 3 | 26 (21) | 14 (35) | ||||
Bortezomib | ||||||
Grade 0 + 1 | 22 (46) | 8 (50) | 0.7 | 14 (54) | 8 (42) | 0.5 |
Grade 2 | 11 (23) | 4 (25) | 7 (27) | 6 (32) | ||
Grade 3 | 15 (31) | 4 (25) | 5 (19) | 5 (26) |