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Table 4 MUTYH mutation prevalence for 82 patients with multiple adenomas (≥10), determined via HRM-PCR and via sequencing

From: Simplifying the detection of MUTYH mutations by high resolution melting analysis

  

Wild type

(%)

Homozygous

(%)

Heterozygous

(%)

Mutations founded

Y179C (exon 7)

96.4 (79/82)

1.2 (1/82)

2.4 (2/82)

 

G396D (exon 13)

92.7 (76/82)

1.2 (1/82)

6.1 (5/82)

 

E410GfsX43 (exon 13)

95.1 (78/82)

0.0 (0/82)

4.9 (4/82)

 

R426C (exon 13)

97.6 (80/82)

0.0 (0/82)

2.4 (2/82)

 

V232F (exon 9)

98.8 (81/82)

0.0 (0/82)

1.2 (1/82)

 

V22M (exon 2)

98.8 (81/82)

0.0 (0/82)

1.2 (1/82)

 

R354GfsX40 (exon 12)

98.8 (81/82)

0.0 (0/82)

1.2 (1/82)

Polymorphism tested

G338H (exon 12)

76.8 (63/82)

0.0 (0/82)

23.2 (19/82)