Figure 6From: PGF2α-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell invasion and endothelial cell function in endometrial cancer Schematic diagram representing the role of ADAMTS1 in epithelial cell invasion and endothelial cell proliferation. ADAMTS1 expression is elevated in the epithelial cells of endometrial adenocarcinoma by PGF2α-FP receptor signalling to the calmodulin-NFAT pathway. In turn ADAMTS1 acts in an autocrine/paracrine manner on tumour epithelial cells to regulate epithelial cell invasion through ECM. Moreover, ADAMTS1 secreted from epithelial cells acts in a paracrine manner on endothelial cells to inhibit cellular proliferation. In addition factors present in the conditioned medium from PGF2α- treated epithelial cells upregulates endothelial ADAMTS1 which in turn can act in an autocrine/paracrine manner to inhibit endothelial cell proliferation.Back to article page