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Table 1 Clinical and tumour characteristics of evaluated cohort (n = 359) and entire cohort on TMA (n = 512) stratified according to survivin nuclear autoscore (SNAS) and cytoplasmic-to-nuclear ratio (CNR) of survivin protein expression.

From: Validation of cytoplasmic-to-nuclear ratio of survivin as an indicator of improved prognosis in breast cancer

 

Entire Cohort

Evaluated Cohort

Evaluated Cohort

 

(n = 512)

(n = 359)

(n = 359)

 

Known

Unknown

p value

SNAS < 4.26

SNAS > 4.26

p value

CNR < 5

CNR > 5

p value

 

(n = 359)

(n = 153)

 

(n = 201)

(n = 158)

 

(n = 198)

(n = 161)

 

Age (Years)

         

Median (Range)

         

< median (25-65)

53(49.1)

175(48.7)

0.520

98(48.8)

77(48.7)

0.541

99(50)

76(47.2)

0.598

> median (65-96)

55(50.9)

184(51.3)

 

103(51.2)

81(51.3)

 

99(50)

85(52.8)

 

Tumour Size

         

0 - 20 mm

255(71.6)

84(79.2)

0.119

148(73.6)

107(69)

0.340

134 (68.7)

121(75.2)

0.180

> 21 mm

101(28.4)

22(20.8)

 

53(26.4)

48(31)

 

61(31.3)

40(24.8)

 

Unknown

3

  

3

  

3

  

Nodal status

         

N0

203(63.6)

66(67.3)

0.502

110(62.1)

93(65.5)

0.537

118(65.9)

85(60.1)

0.337

N1+

116(36.4)

32(32.7)

 

67(37.9)

49(34.5)

 

61(34.1)

55(39.2)

 

Unknown

40

  

19

  

19

  

NHG

         

I&II

237(66.2)

73(67.6)

0.788

145(72.5)

92(58.2)

0.005

119(60.1)

118(73.7)

0.007

III

121(33.8)

35(32.4)

 

55(27.5)

66(41.8)

 

79(39.9)

42(26.2)

 

Unknown

1

        

ER status

         

ER <10%

81(22.9)

25(23.8)

0.843

40(20.2)

41(26.3)

0.176

53(27.1)

28(17.7)

0.038

ER >10%

273(77.1)

80(76.2)

 

158(79.8)

115(73.7)

 

143(72.9)

130(82.3)

 

Unknown

5

  

2

  

2

  

PR Status

         

PR <10%

151(42.7)

50(47.6)

0.368

82(41.4)

69(44.2)

0.595

89 (45.4)

62(39.2)

0.243

PR >10%

203(57.3)

55(52.4)

 

116(58.6)

87(55.8)

 

107(54.6)

96(60.8)

 

Unknown

5

  

2

  

2

  

Ki-67

         

< 10%

128(27.8)

35(37.2)

0.926

82(43.9)

46(30.3)

0.010

55(29.2)

73(48.3)

<0.001

> 10%

211(62.2)

59(62.8)

 

105(56.1)

106(69.7)

 

133(70.7)

78(51.6)

 

Unknown

20

  

10

  

10

  

Her2 IHC

         

Normal/weak (0 - 2+)

285(80.5)

81(77.1)

0.451

166(83.9)

119(76.3)

0.075

149(76.1)

136(86.1)

0.018

Overexpressed (3+)

69(19.5)

24(22.9)

 

32(16.1)

37(23.7)

 

47(23.9)

22(13.9)

 

Unknown

5

  

2

  

2

  
  1. Abbreviations: SNAS = Survivin Nuclear Autoscore, CNR = Cytoplasmic to Nuclear Ratio, N0 = node negative, N1+ = node positive, NHG = Nottingham Harris Grade, ER = estrogen receptor, PR = progesterone receptor, Her2 IHC = Her 2 immunohistochemistry