Evaluation of Best Supportive Care and Systemic Chemotherapy as Treatment Stratified according to the retrospective Peritoneal Surface Disease Severity Score (PSDSS) for Peritoneal Carcinomatosis of Colorectal Origin

Table 4 Analysis of overall survival from diagnosis of carcinomatosis to last follow-up in 167 patients with peritoneal carcinomatosis of colonic origin

Characteristics	n	Median Survival (Months)	P (Univariate)	P (Multivariate) RR [CI]
Sex			0.45
Male	93	8
Female	74	8
Age (Years)			0.58
< 60	85	8
≥ 60	82	8
Disease Presentation			0.45
Synchronous	52	7
Metachronous	115	8
Location			0.07
Colon	123	8
Rectum	44	7
Site of Metastases			0.15
Peritoneum Only	64	7
Peritoneum+Lung/Liver	67	8
Peritoneum+Other	36	9
Systemic Chemotherapy			0.003
None	83	5
5FU/L	42	11
Modern	42	12
Clinical Symptoms			< 0.001
Asymptomatic	55	18
Mild	78	6
Severe	34	3
Extent of Carcinomatosis			0.002
PCI < 10	103	6
PCI 10 to 20	47	11
PCI > 20	17	4
Histopathology			0.003
Well Differentiated	19	7
Moderately Differentiated	89	11
Poorly Differentiated/Signet	59	6
PSDSS Stage			0.003	0.001
Stage I	6	39		2.1 [1.3 - 4.9]
Stage II	53	19
Stage III	33	7
Stage IV	75	4
PSDSS Stage			< 0.001	< 0.001
Stage I/II	59	22		2.8 [1.5 - 5.4]
Stage III/IV	108	5

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