Table 1 P53 targets differentially expressed in melanoma metastases

Apoptosis

1

NM_001040619.1

ATF3

Activating transcription factor 3, transcript variant 4

4.62

0.0042

2

NM_003879.3

CFLAR/FLIP

CASP8 and FADD-like apoptosis regulator

3.10

0.0063

3

NM_004324.3

BAX

BCL2-associated X protein, transcript variant beta

-3.92

0.0127

4

NM_138578.1

BCL2L1

BCL2-like 1 (Bcl-xL), transcript variant 1

-5.77

0.0144

5

NM_001226.3

CASP6

Caspase 6, transcript variant alpha

-13.07

4.98E-05

6

NM_033340.2

CASP7

Caspase 7, transcript variant beta

-3.69

0.0465

7

NM_001080125.1

CASP8

Caspase 8, transcript variant G

-11.38

2.28E-05

8

NM_033356.3

CASP8

Caspase 8, transcript variant C

-2.96

0.0273

9

NM_001007277.1

EI24

Etoposide induced 2.4 mRNA, transcript variant 2

-2.81

0.0245

10

NM_021127.1

PMAIP1

Phorbol-12-myristate-13-acetate-induced protein 1 (Noxa)

12.18

0.0063

11

NM_000314.4

PTEN

Phosphatase and tensin homolog

-3.29

0.0062

12

NM_003840.3

TNFRSF10D

Tumor necrosis factor receptor superfamily, member 10d

-29.89

8.37E-07

13

NM_004881.2

TP53I3

Tumor protein p53 inducible protein 3, transcript variant 1

-4.50

0.0097

Cell cycle, proliferation and differentiation

14

NM_033031.2

CCNB3

Cyclin B3, transcript variant 3

-8.38

1.47E-04

15

NM_033031.2

CCNB3

Cyclin B3, transcript variant 3

-10.79

1.18E-04

16

NM_001759.2

CCND2

Cyclin D2

76.10

1.73E-07

17

NM_001238.1

CCNE1

Cyclin E1, transcript variant 1

-7.61

2.07E-10

18

NM_057749.1

CCNE2

Cyclin E2

3.54

0.0476

19

NM_199246.1

CCNG1

Cyclin G1, transcript variant 2

-5.75

0.0146

20

NM_004354.1

CCNG2

Cyclin G2

-10.66

2.10E-04

21

NM_001798.2

CDK2

Cyclin-dependent kinase 2, transcript variant 1

-4.09

0.0476

22

NM_001798.2

CDK2

Cyclin-dependent kinase 2, transcript variant 1

-17.99

0.0017

23

NM_058197.3

CDKN2A

Cyclin-dependent kinase inhibitor 2A, transcript variant 3

4.97

0.0202

24

NM_058195.2

CDKN2A

Cyclin-dependent kinase inhibitor 2A, transcript variant 4

-7.09

0.0351

25

NM_015675.2

GADD45B

Growth arrest and DNA-damage-inducible, beta

7.41

0.0020

26

NM_006705.2

GADD45G

Growth arrest and DNA-damage-inducible, gamma

11.13

0.0154

27

NM_002592.2

PCNA

Proliferating cell nuclear antigen, transcript variant 1

-7.25

4.32E-04

28

NM_182649.1

PCNA

Proliferating cell nuclear antigen, transcript variant 2

-4.53

0.0219

29

NM_000321.2

RB1

Retinoblastoma 1

-5.85

0.0097

DNA repair

30

NM_138292.3

ATM

Ataxia telangiectasia mutated, transcript variant 2

4.49

0.0328

31

NM_007306.2

BRCA1

Breast cancer 1, early onset, transcript variant BRCA1-exon4

-3.56

0.0371

Immunity and defense

32

NM_001024844.1

CD82

CD82 molecule, transcript variant 2

-4.80

0.0127

33

NM_002996.3

CX3CL1

Chemokine (C-X3-C motif) ligand 1

9.44

2.67E-05

34

NM_153201.1

HSPA8

Heat shock 70kDa protein 8, transcript variant 2

-3.47

0.0350

35

NM_006597.3

HSPA8

Heat shock 70kDa protein 8, transcript variant 1

-3.31

0.0100

36

NM_001098631.1

IRF5

Interferon regulatory factor 5, transcript variant 7

13.39

3.78E-04

37

NM_182826.1

SCARA3

Scavenger receptor class A, member 3, transcript variant 2

6.60

0.0139

38

NM_003246.2

THBS1

Thrombospondin 1

81.54

1.31E-08

39

NM_003247.2

THBS2

Thrombospondin 2

4.16

0.0408

Metabolism

40

NM_020128.1

MDM1

Mdm4, transformed 3T3 cell double minute 1, transcript variant 2

-3.98

0.0146

41

NM_020128.1

MDM1

Mdm4, transformed 3T3 cell double minute 1, transcript variant 2

7.64

0.0023

42

NM_004530.2

MMP2

Matrix metallopeptidase 2

-12.58

0.0017

43

NM_000603.3

NOS3

Nitric oxide synthase 3

11.77

4.62E-05

44

NM_033239.2

PML

Promyelocytic leukemia, transcript variant 9

-6.24

2.81E-04

45

NM_001034.1

RRM2

Ribonucleotide reductase M2 polypeptide

-3.38

0.0476

46

NM_005063.4

SCD

Stearoyl-CoA desaturase

-4.04

0.0039

Transcription regulation

47

NM_006210.1

PEG3

Paternally expressed 3

42.85

2.28E-05

48

NM_003068.3

SNAI2/SLUG

Snail homolog 2

-27.69

9.45E-07

49

NM_004295.3

TRAF4

TNF receptor-associated factor 4

3.75

0.0033

50

NM_152240.1

ZMAT3/WIG1

Zinc finger, matrin type 3, transcript variant 2

-6.97

0.0024

Signal transduction

51

NM_014376.2

CYFIP2

Cytoplasmic FMR1 interacting protein 2, transcript variant 3

17.86

1.20E-08

52

NM_004431.2

EPHA2

EPH receptor A2

5.42

0.0031

53

NM_001005914.1

SEMA3B

Semaphorin 3B, transcript variant 2

156.75

1.59E-08

Unknown function

54

NM_012242.2

DKK1

Dickkopf homolog 1

-17.41

0.0097

55

NM_182915.2

STEAP3

STEAP family member 3, transcript variant 1

8.22

0.0024

56

NM_005802.2

TOPORS

Topoisomerase I binding, arginine/serine-rich

-4.13

0.0350