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Table 3 P53 target genes differentially expressed in melanoma cells with wild-type or mutant P53

From: P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation

Accession No.

Gene Symbol

Gene Name

Fold change (WT vs MT)

p-value

NM_001012271.1

BIRC5

Baculoviral IAP repeat-containing 5 (Survivin), transcript variant 3

2.81

0.03297

 

BIRC5

 

2.42

0.01001

NM_001080125.1

CASP8

Caspase 8, transcript variant G

-5.88

0.02569

NM_001024844.1

CD82

CD82 molecule, transcript variant 2

-19.52

0.03576

NM_001790.3

CDC25C

Cell division cycle 25 homolog C, transcript variant 1

-2.57

0.00007

NM_058195.2

CDKN2A

Cyclin-dependent kinase inhibitor 2A, transcript variant 4

-88.58

0.0159

 

CDKN2A

 

-34.08

2.2E-05

NM_003068.3

SNAI2/SLUG

Snail homolog 2

-8.92

0.00005

NM_005862.2

STAG1

Stromal antigen 1

2.33

0.04536

  1. Fold change in mRNA expression of p53 target genes found to be significantly different in extracts from melanoma cell lines expressing wild-type p53 (IgR3, Mel-RM, MM200, Me1007) compared to melanoma cell lines with null/mutant p53 (Sk-Mel-28, Me4405) (> 2-fold difference, p ≤ 0.05 and FDR = 5.0%). Real-time qRT-PCR verification of selected genes is shown in italics.