Table 3 Cell cycle regulators are more affected by MT19C at earlier times while translation regulators and ribosomes are affected at later times by GSEA.
From: Integrated genomics of ovarian xenograft tumor progression and chemotherapy response
Geneset | NES | P-value | FDR |
|---|---|---|---|
Treat8 vs. Naive8 | Â | Â | Â |
Biocarta (n = 184) | Â | Â | Â |
ATRBRCA pathway | 1.74 | 0.000 | 0.315 |
MTA3 pathway | -1.87 | 0.000 | 0.141 |
GenMapp (n = 107) | Â | Â | Â |
DNA Replication | 1.84 | 0.000 | 0.024 |
G1 to S Cell Cycle Reactome | 1.59 | 0.006 | 0.122 |
Krebs TCA Cycle | 1.49 | 0.033 | 0.219 |
Galactose metabolism | -1.88 | 0.000 | 0.113 |
Oxidative Phosphorylation | -1.68 | 0.002 | 0.139 |
Nuclear Receptors | -1.59 | 0.013 | 0.227 |
Kegg (n = 165) | Â | Â | Â |
Cell Cycle | 1.94 | 0.000 | 0.013 |
Transcription factor targets (n = 614) | Â | Â | Â |
E2F1s | 1.76-2.05 | 0.000 | 0.000-0.008 |
Bach2 | -1.73 | 0.000 | 0.037 |
Treat16 vs. Naive16 | Â | Â | Â |
Genmapp (n = 107) | Â | Â | Â |
Ribosomal proteins | 2.41 | 0.000 | 0.000 |
Aminoacyl tRNA biosynthesis | 2.05 | 0.002 | 0.003 |
Translation Factors | 1.66 | 0.005 | 0.203 |