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Table 2 Pyrosequencing analysis of 20 matched samples: average methylation values of 51 CpGs in CpG island A of RASSF1A, of which 17 CpGs in the promoter and 34 CpGs in the first exon

From: Methylation-associated down-regulation of RASSF1A and up-regulation of RASSF1Cin pancreatic endocrine tumors

 

Average methylation (%)

Cases*

   
 

Promoter

First Exon

CpG island A

N1

4

2

3

T1

2

4

3

N2

34

75

60

T2

20

11

14

N3

29

14

19

T3

37

19

25

N4

2

2

2

T4

23

8

13

N5

37

22

28

T5

59

56

57

N6

27

18

22

T6

29

10

17

N7

40

35

37

T7

53

52

52

N8

47

37

40

T8

77

46

57

N9

43

32

35

T9

46

29

35

N10

35

34

34

T10

49

72

64

N11

37

38

38

T11

38

43

41

N12

28

18

22

T12

42

66

57

N13

25

34

31

T13

67

65

66

N14

4

3

4

T14

49

30

37

N15

36

28

31

T15

50

37

41

N16

14

8

10

T16

10

9

9

N17

3

2

2

T17

3

5

4

N18

4

18

13

T18

32

7

16

N19

10

6

8

T19

25

37

33

N20

25

36

32

T20

43

80

67

  1. *N = normal pancreas, T = PET.