Table 3 Univariate Cox hazard regression analysis for prognostic factors

Gender

male/female

0.031 (0.000-5.569)

0.190

Age

< 60/≥60

1.630 (0.564-4.716)

0.367

Smoking

nonsmoker/current smoker

1.388 (0.306-6.297)

0.671

Tumor size

0-3 cm/> 3 cm

0.766 (0.239-2.455)

0.654

Histological classification

adenocarcinoma/SCC

2.739 (0.781-9.604)

0.115

Invasion to lung membrane

Negative/positive

1.000 (0.221-4.534)

1.000

Differentiation

Mod-well/poor

0.757 (0.182-3.141)

0.701

Lymph node

Negative/positive

1.279 (0.425-3.850)

0.661

Stage classification

stage I/stage II, III, IV

1.001 (0.334-2.996)

0.999

Tumor miR-96

High, > 6.45/low, < 6.45

9.637 (1.963-47.315)

0.005 *

Tumor miR-182

High, > 6.25/low, < 6.25

7.163 (1.597-32.138)

0.010 *

Tumor miR-183

High, > 4.44/low, < 4.44

8.616 (1.918-38.705)

0.005*

Serum miR-96

High, > 5.98/low, < 5.98

5.512 (1.219-24.915)

0.027 *

Serum miR-182

High, > 2.08/low, < 2.08

5.327 (1.181-24.030)

0.030 *

Serum miR-183

High, > 1.84/low, < 1.84

5.972 (1.289-27.658)

0.022 *