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Table 1 Effects of 5-FU on the development of colon tumors in the KAD rat

From: Use of a chemically induced-colon carcinogenesis-prone Apc-mutant rat in a chemotherapeutic bioassay

Treatment

No. of rats

Macroscopic observation

Microscopic observation

  

Multiplicity

Volume (mm3)1

Multiplicity

Volume (mm3)2

    

adenomas

adenocarcinomas

total

adenocarcinoma

Saline

9

5.56 ± 3.43

106.34 ± 68.92

3.11 ± 2.52

3.22 ± 2.77

6.33 ± 4.87

63.85 ± 51.06

50 mg/kg 5-FU

9

6.33 ± 3.04

77.28 ± 57.23

3.78 ± 1.79

2.33 ± 1.94

6.11 ± 2.37

34.40 ± 31.26 3

  1. 1Tumor volume was determined by the formula V = a × b2/2 (V: volume. a: the largest superficial diameter and b: the smallest superficial diameter).
  2. 2Volumes of adenomas were too small to calculate.
  3. 3Adenocarcinoma volumes observed in the 5-FU-treated KAD rats were significantly reduced as compared with those of non-treated rats (p <0.02).