From: Use of a chemically induced-colon carcinogenesis-prone Apc-mutant rat in a chemotherapeutic bioassay
Treatment | No. of rats | Macroscopic observation | Microscopic observation | ||||
---|---|---|---|---|---|---|---|
Multiplicity | Volume (mm3)1 | Multiplicity | Volume (mm3)2 | ||||
adenomas | adenocarcinomas | total | adenocarcinoma | ||||
Saline | 9 | 5.56 ± 3.43 | 106.34 ± 68.92 | 3.11 ± 2.52 | 3.22 ± 2.77 | 6.33 ± 4.87 | 63.85 ± 51.06 |
50 mg/kg 5-FU | 9 | 6.33 ± 3.04 | 77.28 ± 57.23 | 3.78 ± 1.79 | 2.33 ± 1.94 | 6.11 ± 2.37 | 34.40 ± 31.26 3 |