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Table 4 Fit of the model to the data for the 27 blocks with grouped data

From: Systematic review with meta-analysis of the epidemiological evidence relating FEV1decline to lung cancer risk

Block: studya

Measureb

Rangec

FEV1%P Diffd

RR (95%CI)

Fitted RR

Cases observede

Cases fitted

1: BEATY

FEV1%P

>80

(95.33)

1.00

1.00

14.30

14.30

β (SE) =

−0.028 (0.034)

≤80

29.77

0.43 (0.06-3.20)

0.43

1.03

1.03

2: CALABR

FEV1%P

90+

(104.94)

1.00

1.00

24.20

25.71

β (SE) =

0.024 (0.008)

70 to <90

23.90

2.29 (1.24-4.23)

1.76

17.09

13.98

χ 2 (df) =

1.04 (1)

<70

49.60

2.90 (1.34-6.27)

3.25

8.50

10.11

3: CARET f

FEV1%P

80+

(100.75)

1.00

1.00

35.35

34.69

β (SE) =

0.022 (0.007)

70 to <80

24.89

1.54 (0.80-2.63)

1.74

14.59

16.20

χ 2 (df) =

0.22 (2)

60 to <70

34.92

2.25 (1.20-4.19)

2.18

12.39

11.77

  

<60

49.07

3.08 (1.42-6.69)

2.99

6.92

6.59

4: CARET g

FEV1%P

80+

(91.97)

1.00

1.00

16.66

15.78

β (SE) =

0.012 (0.006)

70 to <80

16.94

1.05 (0.56-1.96)

1.22

19.07

20.99

χ 2 (df) =

0.25 (2)

60 to <70

26.77

1.33 (0.74-2.42)

1.36

24.04

23.27

  

<60

47.77

1.66 (0.95-2.89)

1.74

34.62

34.35

5: CARTA

FEV1/FVC

90+

(99.82)

1.00

1.00

3.72

7.84

β (SE) =

0.072 (0.049)

80 to <90

−0.99

3.87 (1.12-15.05)

0.93

5.83

2.95

χ 2 (df) =

5.25 (1), p<0.05

<80

9.64

5.18 (1.56-19.66)

2.00

6.66

5.42

6: FINKEL

FEV1%P

100+

(109.54)

1.00

1.00

7.75

6.71

β (SE) =

0.009 (0.011)

80 to <100

18.00

0.89 (0.39-2.18)

1.17

13.43

15.32

χ 2 (df) =

0.47 (1)

<80

41.17

1.35 (0.57-3.36)

1.44

11.17

10.31

9: LANGE

FEV1%P

80+

(100.99)

1.00

1.00

47.92

48.77

β (SE) =

0.020 (0.004)

40 to <80

32.64

2.10 (1.30-3.40)

1.93

24.67

23.05

χ 2 (df) =

0.17 (1)

<40

69.50

3.90 (2.20-7.20)

4.05

13.46

14.23

11: MANNIN

FEV1%P

80+

(100.24)

1.00

1.00

84.98

84.94

β (SE) =

0.022 (0.006)

<80

33.97

2.12 (1.44-3.11)

2.12

35.83

35.87

12: MRFIT

FEV1 unnormalised,ml

≥3674

(105.91)

1.00

1.00

27.01

26.50

β (SE) =

0.031 (0.005)

3307 to 3673

10.05

1.31 (0.82-2.10)

1.37

45.30

46.34

χ 2 (df) =

0.85 (3)

2985 to 3306

15.92

1.50 (0.95-2.36)

1.64

54.20

58.27

  

2606 to 2984

22.21

2.13 (1.39-3.26)

2.00

80.62

74.45

  

≤2605

37.59

3.13 (2.07-4.72)

3.23

106.01

107.59

13: NOMURA

FEV1%P

103.5+

(113.14)

1.00

1.00

22.16

23.76

β (SE) =

0.018 (0.005)

94.5 to <103.5

14.40

1.00 (0.60-1.90)

1.29

23.34

32.35

χ 2 (df) =

11.40 (2), p<0.01

84.5 to <94.5

23.45

2.50 (1.50-4.10)

1.52

44.66

29.09

  

<84.5

43.11

2.10 (1.30-3.50)

2.15

49.51

54.48

14: PETO

SDs of FEV1/h3 below average

Above average

(103.85)

1.00

1.00

32.15

39.80

β (SE) =

0.018 (0.008)

0 to 1

15.05

2.17 (1.40-3.38)

1.32

46.77

35.18

χ 2 (df) =

6.81 (2), p<0.05

1 to 2

34.30

2.02 (0.97-3.90)

1.88

9.93

11.43

  

2+

65.85

1.89 (0.37-5.90)

3.35

2.03

4.47

15: PURDUE

FEV1%P

80+

(100.13)

1.00

1.00

1698.83

1698.83

β (SE) =

0.023 (0.002)

<80

31.76

2.06 (1.77-2.39)

2.06

189.24

189.24

16: RENFRE h

FEV1%P

Quintile 5

(116.04)

1.00

1.00

31.54

35.64

β (SE) =

0.015 (0.003)

Quintile 4

13.70

1.36 (0.86-2.13)

1.22

42.34

42.97

χ 2 (df) =

1.48 (3)

Quintile 3

23.79

1.81 (1.18-2.78)

1.42

55.91

49.41

  

Quintile 2

35.19

1.93 (1.27-2.94)

1.67

62.88

61.57

  

Quintile 1

57.75

2.53 (1.69-3.79)

2.32

79.83

82.90

17: RENFRE i

FEV1%P

Quintile 5

(119.96)

1.00

1.00

6.22

15.69

β (SE) =

0.011 (0.005)

Quintile 4

13.53

3.63 (1.49-8.84)

1.15

21.19

16.98

χ 2 (df) =

8.39 (3), p<0.05

Quintile 3

24.26

4.03 (1.68-9.67)

1.29

24.88

20.11

  

Quintile 2

36.19

4.12 (1.73-9.81)

1.47

27.21

24.40

  

Quintile 1

59.75

4.37 (1.84-10.42)

1.88

27.40

29.72

18: SKILLR

FEV1%P

85+

(100.81)

1.00

1.00

1.99

1.99

β (SE) =

0.034 (0.017)

< = 70

44.85

4.50 (0.99-20.37)

4.50

8.97

8.97

19: SPEIZE h

Mean FEV1,â„“.j

4.07

(109.98)

1.00

1.00

2.09

3.72

β (SE) =

0.048 (0.014)

3.54

9.02

4.33 (1.19-23.71)

1.54

9.35

5.93

χ 2 (df) =

4.49 (2)

3.18

16.84

2.10 (0.45-12.96)

2.25

3.85

7.35

  

2.55

33.30

9.60 (2.93-49.67)

4.98

21.90

20.19

20: SPEIZE i

Mean FEV1,â„“.j

2.90

(112.16)

1.00

1.00

0.50

0.62

β (SE) =

0.054 (0.029)

2.57

10.10

3.17 (0.25-166.25)

1.73

1.36

0.92

χ 2 (df) =

0.52 (2)

2.34

19.47

2.05 (0.11-121.19)

2.86

0.85

1.48

  

1.95

35.49

8.94 (1.20-396.75)

6.80

5.74

5.43

21: STAVEM

Mean FEV1%P

121.90

(121.90)

1.00

1.00

8.99

6.19

β (SE) =

0.021 (0.008)

106.60

15.30

0.78 (0.29-2.07)

1.38

6.89

8.42

χ 2 (df) =

4.48 (2)

95.30

26.60

0.67 (0.24-1.86)

1.76

6.00

10.86

  

75.70

46.20

2.23 (1.03-4.83)

2.67

20.40

16.82

24: TOCKMA

FEV1%P

>85

(102.90)

1.00

1.00

22.27

22.72

β (SE) =

0.021 (0.010)

60 to 85

27.52

2.57 (0.87-7.56)

1.78

3.82

2.70

χ 2 (df) =

0.60 (1)

<60

57.43

2.72 (0.76-9.74)

3.34

2.61

3.27

25: VANDEN k

FEV1 unnormalised, â„“

3.85+

(105.38)

1.00

1.00

5.34

4.12

β (SE) =

0.018 (0.013)

3.35-3.85

7.12

1.19 (0.41-3.49)

1.14

8.82

6.47

χ 2 (df) =

2.23 (3)

2.85-3.35

9.72

0.76 (0.27-2.14)

1.19

10.80

13.02

  

2.35-2.85

11.23

0.76 (0.27-2.14)

1.22

11.01

13.64

  

<2.35

31.46

1.49 (0.55-4.05)

1.75

13.75

12.46

26: VANDEN l

FEV1 unnormalised, â„“

3.85+

(106.21)

1.00

1.00

6.84

10.05

β (SE) =

0.010 (0.007)

3.35-3.85

5.47

1.43 (0.60-3.42)

1.06

18.46

20.11

χ 2 (df) =

1.63 (3)

2.85-3.35

10.13

1.76 (0.78-3.93)

1.11

41.81

38.92

  

2.35-2.85

14.67

1.80 (0.83-3.91)

1.17

81.93

78.13

  

<2.35

35.27

2.04 (0.92-4.54)

1.44

45.94

47.77

27: VANDEN m

FEV1 unnormalised, â„“

3.85+

(104.52)

1.00

1.00

24.68

29.86

β (SE) =

0.012 (0.003)

3.35-3.85

9.72

1.32 (0.82-2.12)

1.12

55.20

56.66

χ 2 (df) =

1.69 (3)

2.85-3.35

14.29

1.43 (0.94-2.19)

1.18

141.35

140.99

  

2.35-2.85

21.15

1.62 (1.08-2.44)

1.28

267.93

255.94

  

<2.35

40.79

1.89 (1.24-2.87)

1.61

167.40

173.12

28: VANDEN n

FEV1 unnormalised, â„“

2.75+

(105.01)

1.00

1.00

7.50

5.82

β (SE) =

−0.004 (0.016)

2.35-2.75

7.32

0.76 (0.30-1.90)

0.97

11.34

11.31

χ 2 (df) =

2.92 (3)

2.05-2.35

8.70

0.60 (0.27-1.34)

0.97

29.24

36.34

  

1.65-2.05

8.73

0.92 (0.40-2.12)

0.97

21.57

17.51

  

<1.65

22.96

0.76 (0.33-1.78)

0.91

18.43

17.11

29: VANDEN o

FEV1 unnormalised, â„“

2.35-2.75p

(97.83)

1.00

1.00

11.85

9.95

β (SE) =

0.026 (0.011)

2.05-2.35

3.02

1.25 (0.61-2.57)

1.08

19.20

13.93

χ 2 (df) =

6.55 (2), p<0.05

1.65-2.05

5.49

0.54 (0.24-1.21)

1.15

11.29

20.27

  

<1.65

27.83

1.92 (0.92-4.02)

2.05

17.24

15.43

30: VANDEN q

FEV1 unnormalised, â„“

2.75+

(103.28)

1.00

1.00

9.63

21.54

β (SE) =

0.019 (0.004)

2.35-2.75

9.74

2.90 (1.46-5.77)

1.20

51.91

47.91

χ 2 (df) =

8.13 (3), p<0.05

2.05-2.35

15.25

3.33 (1.72-6.48)

1.33

86.50

77.06

  

1.65-2.05

21.26

3.33 (1.74-6.37)

1.48

166.89

166.21

  

<1.65

41.80

4.76 (2.47-9.19)

2.17

107.33

109.53

31: WILES

FEV1/h3, cl/m3

56+

(105.56)

1.00

1.00

23.36

25.12

β (SE) =

0.021 (0.008)

43-56

17.66

1.69 (0.97-2.94)

1.46

25.01

23.20

χ 2 (df) =

1.02 (2)

30-43

36.24

2.65 (1.29-5.20)

2.17

11.02

9.68

  

0-30

70.93

2.87 (0.56-9.30)

4.54

1.97

3.34

32: WILSON g

FEV1%P

80+

(100.14)

1.00

1.00

10.78

10.85

β (SE) =

0.008 (0.007)

50 to <80

30.94

1.30 (0.64-2.65)

1.28

22.87

22.73

χ 2 (df) =

0.002 (1)

<50

62.07

1.65 (0.70-3.90)

1.65

9.21

9.28

TOTAL r

FEV1%P

 

(106.16)

  

388.51

431.45

χ 2 (df) =

8.43 (5)

 

0.01-10

  

259.67

257.83

   

10.01-20

  

666.20

658.51

   

20.01-30

  

742.1

694.76

   

30.01-40

  

364.31

358.07

   

>40

  

542.36

562.52

  1. a For each block, the block number and study reference code is shown. Also shown in columns 1 and 2 are the values of β, the fitted slope of the relationship of log RR to the estimated mean difference (see note d), and the SE of β, and also, for blocks with more than two levels, the results of the goodness-of-fit test.
  2. b This is the measure the data were originally recorded in.
  3. c The range of values of the measure for which results were available.
  4. d The estimated mean difference of FEV1%P between the comparison level and the level of interest. Shown in brackets is the estimate of FEV1%P for the comparison level.
  5. e These are pseudo-numbers of cases estimated using the method of Hamling et al.[16].
  6. f FEV1/FVC ≥0.70.
  7. g FEV1/FVC<0.70.
  8. h Males.
  9. i Females.
  10. j RRs were given by quartiles of FEV1 residuals calculated from a prediction equation. Mean FEV1 levels for each quartile were used to derive the differences in FEV1%P.
  11. k Male never smokers.
  12. l Male former smokers.
  13. m Male current smokers.
  14. n Female never smokers.
  15. o Female former smokers.
  16. p There were no deaths in the highest quintile (2.75+ â„“).
  17. q Female current smokers.
  18. r Total over all blocks with more than two levels.
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