Skip to main content

Table 5 Testing for significance of variation in β by various factors considered one at a time

From: Systematic review with meta-analysis of the epidemiological evidence relating FEV1decline to lung cancer risk

Factor

Level

Blocks includeda

Nb

β (95% CI)

Deviancec

None

All

1-32

32

0.018 (0.016-0.021)

44.01

Sex

Male

1,3-6,12-16,19,21,23-27,31

18

0.019 (0.016-0.022)

42.33

 

Female

17,20,22,28-30

6

0.015 (0.008-0.022)

 
 

Both

2,7-11,18,32

8

0.018 (0.012-0.024)

 

Publication year

<1990

1,14,18-20,24

6

0.025 (0.012-0.038)

40.12

 

1990-1994

5,7-9,13,25-31

12

0.016 (0.012-0.020)

 
 

1995+

2-4,6,10-12,15-17,21-23,32

14

0.019 (0.016-0.023)

 

Mean age

<50

5,6,11,12,14,15,19-21,31

10

0.024 (0.020-0.028)

29.12**

 

50-59

1,3,4,9,13,16-18,25-30

14

0.015 (0.012-0.018)

 
 

60+

2,7,8,10,22-24,32

8

0.017 (0.011-0.022)

 

Quality score

8 or 9

3,4,7-9,11-13,16,17,19,20,22,23,

25–30,32

21

0.017 (0.014-0.020)

40.20

 

5 to 7

1,2,5,6,10,14,15,18,21,24,31

11

0.022 (0.017-0.026)

 

Continent

North America

1,3,4,6-8,10-13,18-20,22-30,32

23

0.018 (0.014-0.021)

43.46

 

Other

2,5,9,14-17,21,31

9

0.019 (0.016-0.023)

 

Disease fatality

Deaths

1,5,9,12,14,15,19-21,24,31

11

0.024 (0.020-0.027)

28.99**

 

Incidence

13,22,23,25-30

9

0.015 (0.011-0.020)

 
 

Both

2-4,6-8,10,11,16-18,32

12

0.015 (0.012-0.019)

 

Population type

General

1,7-9,11,14,16,17,19-21,25-30

17

0.016 (0.013-0.019)

37.74*

 

Other

2-6,10,12,13,15,18,22-24,31,32

15

0.021 (0.018-0.025)

 

Exposed to lung carcinogens

Yes

3-6

4

0.016 (0.006-0.025)

43.44

 

No

1,2,7-32

28

0.019 (0.016-0.021)

 

Follow-up period

1-15

2,9,10,18-20,24,32

8

0.020 (0.013-0.027)

41.72

 

16-23

3-6,11,13,16,17,22,23,31

11

0.016 (0.012-0.021)

 
 

24+

1,7,8,12,14,15,21,25-30

13

0.019 (0.016-0.023)

 

Adjusted for smoking

Yesd

2-4,7-13,15-17,19,20,22-30,32

25

0.018 (0.016-0.021)

43.98

 

No

1,5,6,14,18,21,31

7

0.019 (0.009-0.029)

 

Measure of FEV1 reported

FEV1%P

1-4,6-11,13,15-18,21-24,32

20

0.018 (0.015-0.021)

43.93

 

Other

5,12,14,19,20,25-31

12

0.019 (0.014-0.024)

 

Weight of β

<125

1,5-7,18-20,24,25,28,29

11

0.021 (0.010-0.031)

43.54

 

125-250

2,3,8,10,14,21-23,26,31,32

11

0.017 (0.012-0.023)

 
 

250+

4,9,11-13,15-17,27,30

10

0.019 (0.015-0.022)

 

Original data recorded as

Regression coefficient

7,8,10,22,23

5

0.017 (0.008-0.026)

43.02

 

RR (CI)

1-4,9,11-13,15-18,21,24-30,32

21

0.018 (0.016-0.021)

 
 

SMR/SIR

5,6,14,19,20,31

6

0.022 (0.011-0.034)

 
  1. a See Tables 3 and 4 for definition of blocks.
  2. b Number of estimates of β which are combined.
  3. c The significance of the factor is assessed by comparing the deviance for the model including that factor and the deviance for the null (no factor) model and is indicated by *p<0.05 **p<0.01 *** p<0.001.
  4. d This includes blocks which relate to the whole population, current smokers or ever smokers which adjust at least for a measure of dose, such as cigs/day or pack yrs, and blocks which are restricted to nonsmokers.