Figure 1

Immunohistochemical staining of BRMS1 in benign nevi showing cytoplasmic and nuclear (A,) and nuclear only expression (B), primary melanomas with cytoplasmic expression (C, D) and metastatic melanomas demonstrating cytoplasmic and nuclear (E) and cytoplasmic only immunoreactivity (F). In the two melanoma cell lines (G, H) BRMS1 is localized mainly in the nucleus, although some cytoplasmic expression is also present.