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Table 6 Correlation between estrogen and progesterone receptor status and MembErbB-2 expression

From: Clinical relevance of ErbB-2/HER2 nuclear expression in breast cancer

 

MembErbB-2 (IF)a, n (%)

Total N (%)

P value

MembErbB-2 (IHC)b, n (%)

Total N (%)

P value

 

Negative

Positive

  

Negative

Positive

  

ERc expression

        

   Negative

54 (23.90)d

20 (8.8)

74 (32.7)

0.001e

54 (26.8)

16 (8.0)

70 (34.8)

0.002

   Positive

140 (61.9)

12 (5.3)

152 (67.3)

 

121 (60.2)

10 (5.0)

131 (65.2)

 

PRf expression

        

   Negative

90 (39.8)

24 (10.6)

114 (50.4)

0.003

88 (43.8)

20 (10.0)

108 (53.7)

0.011

   Positive

104 (46.0)

8 (3.5)

112 (49.6)

 

87 (43.2)

6 (3.0)

93 (46.2)

 
  1. a IF: Immunofluorescence staining performed with C-18 antibody. b IHC: Immunohistochemistry staining performed with RBT-HER2 antibody. c ER: Estrogen receptor. d Percentage of the total cohort. e Correlation between variables was determined by χ2 analysis. f PR: Progesterone receptor