Table 2 Stratification analysis for associations between genotypes of the LAMB3-miR-218 pathway and cervical cancer risk in the recessive genetic model

Age, years

≤46 (Mean)

747/623

136/131

0.84 (0.64-1.11)

0.215

0.364

774/669

109/85

1.02 (0.74-1.40)

0.919

0.740

>46 (Mean)

593/527

89/110

0.77 (0.56-1.06)

0.111

602/564

80/73

1.00 (0.69-1.45)

0.995

Age at primiparity, years

≤24 (Mean)

797/568

136/131

0.73 (0.56-0.96)

0.022

0.452

822/625

111/74

1.12 (0.82-1.54)

0.482

0.460

>24 (Mean)

468/566

76/106

0.86 (0.62-1.20)

0.386

481/591

63/81

0.91 (0.63-1.32)

0.621

Menopausal status

Premenopausal

962/685

164/155

0.73 (0.57-0.94)

0.013

0.425

986/743

140/97

1.00 (0.75-1.34)

0.981

0.635

Postmenopausal

366/463

61/86

0.90 (0.62-1.32)

0.600

381/488

46/61

1.09 (0.70-1.70)

0.696

BMI, kg/m ²

< 25

1026/759

175/157

0.79 (0.62-1.00)

0.054

0.715

1061/810

140/106

1.00 (0.75-1.32)

0.973

0.739

≥ 25

288/390

47/84

0.74 (0.50-1.12)

0.152

295/422

40/52

1.02 (0.64-1.63)

0.939

Histology

CINIII

129/1150

32/241

1.06 (0.68-1.66)

0.789

0.169

137/1233

24/158

1.32 (0.80-2.16)

0.274

0.409

SCC

1068/1150

170/241

0.74 (0.59-0.92)

0.008

1096/1233

142/158

0.95 (0.73-1.22)

0.673

Non-squamous

138/1150

23/241

0.75 (0.46-1.22)

0.240

138/1233

23/158

1.18 (0.71-1.96)

0.526

FIGO stage

I

633/1150

97/241

0.70 (0.53-0.91)

0.008

0.796

645/1233

85/158

0.94 (0.70-1.27)

0.689

0.341

II

464/1150

75/241

0.72 (0.54-0.97)

0.028

478/1233

61/158

0.96 (0.69-1.35)

0.830

III~IV

43/1150

5/241

0.43 (0.15-1.28)

0.129

39/1233

9/158

1.97 (0.83-4.71)

0.126

Tumor size, cm

< 4

801/1150

139/241

0.78 (0.61-0.99)

0.043

0.695

840/1233

100/158

0.88 (0.66-1.16)

0.365

0.100

≥ 4

428/1150

69/241

0.71 (0.53-0.97)

0.031

426/1233

71/158

1.25 (0.91-1.72)

0.176

Pelvic LN

Negative

965/1150

174/241

0.83 (0.66-1.04)

0.098

0.095

1002/1233

137/158

1.00 (0.77-1.29)

0.970

0.819

Positive

309/1150

39/241

0.55 (0.37-0.80)

0.002

308/1233

40/158

0.96 (0.64-1.42)

0.828

LVSI

Negative

750/1150

132/241

0.80 (0.63-1.02)

0.073

0.305

783/1233

99/158

0.93 (0.70-1.24)

0.632

0.379

Positive

390/1150

56/241

0.64 (0.46-0.89)

0.008

387/1233

59/158

1.06 (0.75-1.50)

0.755

Depth of cervical stromal invasion

≤ 1/2

584/1150

99/241

0.75 (0.57-0.98)

0.037

0.898

598/1233

85/158

1.08 (0.81-1.45)

0.602

0.709

> 1/2

670/1150

111/241

0.74 (0.57-0.96)

0.022

690/1233

91/158

0.94 (0.70-1.26)

0.660

ER expression

Negative

647/1150

102/241

0.71 (0.55-0.92)

0.011

0.146

671/1233

78/158

0.85 (0.62-1.15)

0.289

0.365

Positive

50/1150

13/241

1.01 (0.51-1.98)

0.982

54/1233

9/158

1.35 (0.65-2.81)

0.428

PR expression

Negative

677/1150

110/241

0.73 (0.56-0.94)

0.014

0.407

703/1233

84/158

0.87 (0.65-1.18)

0.370

0.836

Positive

20/1150

5/241

0.94 (0.32-2.80)

0.911

22/1233

3/158

1.13 (0.33-3.84)

0.851