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Figure 2 | BMC Cancer

Figure 2

From: Potential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analyses

Figure 2

Kaplan-Meier survival analysis of TIMELESS expression using the GOBO online tool, which comprises of pooled data from 1881 breast cancer cases from 11 public data sets. Samples were stratified into tertiles based on TIMELESS expression level. The log-rank test was performed in all tumor samples as well as in different tumor subtypes using distant metastasis-free survival (DMFS) as the endpoint. High TIMELESS expression is significantly associated with lower DMFS over time among (A) all cases regardless of tumor ER- and LN-positivity (P = 1.65E-3), (B) cases with ER-positive tumors (P = 2.20E-4), (C) cases with LN-negative tumors (P = 9.00E-5), and (D) cases with ER-positive and LN-negative tumors (P = 1.00E-5).

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