Table 1 The IC ₅₀ values of various chemotherapeutics in mouse and human melanoma cells with different status of HSF1

B16F10

Unmodified

10 ± 3,46

4,3 ± 0,71

19 ± 2,64

5,03 ± 1,88

9,73 ± 3,4

Neo

10,8 ± 3,3

3,6 ± 0,87

16 ± 2

6,47 ± 3,41

8,77 ± 1,97

hHSF1

31,5 ± 5,07*

3 ± 0,28

30,67 ± 5,03*

6,77 ± 1,78

10,8 ± 3,68

aHSF1

8,97 ± 1,76

3,13 ± 0,42

20,67 ± 5,03

6,63 ± 2,92

7,63 ± 1,86

hHSF1-DN

39 ± 1,41*

4,7 ± 1,1

29,67 ± 0,58*

6,9 ± 0,14

7,9 ± 1,65

WM793B

Unmodified

20,67 ± 5,77

7 ± 2,65

30,2 ± 5,37

5,6 ± 1,41

3,85 ± 0,07

Neo

17,83 ± 6,33

6,33 ± 1,6

27,47 ± 6,57

4,55 ± 1,34

3,65 ± 0,07

hHSF1

71,33 ± 3,06*

4,75 ± 0,07

58,2 ± 3,11*

5,4 ± 0,71

3,3 ± 0,63

aHSF1

25,33 ± 2,31

7,75 ± 2,47

41,6 ± 6,4

4,3 ± 1,56

3,7 ± 0,14

hHSF1-DN

75 ± 1,41*

5,4 ± 1,41

77 ± 4,24*

7,47 ± 4,1

3,55 ± 0,21

1205Lu

Unmodified

33,47 ± 2,54

2,375 ± 0,04

25 ± 5,55

6,93 ± 1,33

3,2 ± 0,85

Neo

31,13 ± 3,31

2,6 ± 0,96

19,37 ± 7,99

4,37 ± 0,51

3,15 ± 1,06

hHSF1

66 ± 11,31*

3,5 ± 0,14

52,67 ± 7,02*

6,93 ± 2,69

2,55 ± 0,07

aHSF1

24,8 ± 1,7

3,6 ± 1,13

22,33 ± 0,5

5,6 ± 1,64

3,15 ± 0,92

hHSF1-DN

54,5 ± 20,5*

4,67 ± 1,1

38 ± 2*

5,87 ± 1,01

3,65 ± 0,64