Table 3 Association between methylation patterns of MLH1 and MGMT and mutational status
Methylation status | Mutational status | N (%) | p | |
|---|---|---|---|---|
BRAF V600E* | ||||
MLH1 | Methylated | Positive | 4/20 (20%) | 0.048 |
Negative | 10/19 (53%) | |||
Unmethylated | Positive | 16/20 (80%) | ||
Negative | 9/19 (47%) | |||
MGMT | Methylated | Positive | 14/20 (70%) | 0.333 |
Negative | 10/19 (53%) | |||
Unmethylated | Positive | 6/20 (30%) | ||
Negative | 9/19 (47%) | |||
RET/PTC* | ||||
MLH1 | Methylated | Positive | 8/16 (50%) | 1.000 |
Negative | 10/19 (53%) | |||
Unmethylated | Positive | 8/16 (50%) | ||
Negative | 9/19 (47%) | |||
MGMT | Methylated | Positive | 9/16 (56%) | 1.000 |
Negative | 10/19 (53%) | |||
Unmethylated | Positive | 7/16 (44%) | ||
Negative | 9/19 (47%) | |||
Transitions (IDH1 + NRAS) | ||||
MLH1 | Methylated | Positive | 5/11 (45%) | 1.000 |
Negative | 13/25 (52%) | |||
Unmethylated | Positive | 6/11 (55%) | ||
Negative | 12/25 (48%) | |||
MGMT | Methylated | Positive | 9/11 (82%) | 0.268 |
Negative | 15/25 (60%) | |||
Unmethylated | Positive | 2/11 (18%) | ||
Negative | 10/25 (40%) | |||
Point mutations (BRAF + IDH1 + NRAS) | ||||
MLH1 | Methylated | Positive | 14/41 (34%) | 0.199 |
Negative | 13/25 (52%) | |||
Unmethylated | Positive | 27/41 (66%) | ||
Negative | 12/25 (48%) | |||
MGMT | Methylated | Positive | 29/41 (71%) | 0.426 |
Negative | 15/25 (60%) | |||
Unmethylated | Positive | 12/41 (29%) | ||
Negative | 10/25 (40%) | |||