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Table 3 Univariate and multivariate Cox regression analyses GAS5 for DFS or OS of patients in study cohort (n = 89)

From: Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer

Variables

DFS

OS

 

HR

95% CI

Pvalue

HR

95% CI

Pvalue

Univariate analysis

    

.

 

Age (<50 years vs. >50 years)

1.122

0.659-1.910

0.671

1.057

0.589-1.899

0.852

Gender (male vs. female)

1.584

0.907-2.768

0.106

1.739

0.933-3.240

0.082

Location (Distal vs. Middle + Proximal)

1.232

0.811-1.872

0.327

1.498

0.830-2.702

0.180

tumor size (>5 cm vs. <5 cm)

1.493

0.876-2.543

0.141

1.260

0.938-1.692

0.124

Histologic differentiation (Well + Moderately vs. Poorly + Undifferentiated)

0.743

0.428-1.288

0.289

0.798

0.436-1.458

0.463

Invasion depth (T1 + T2 vs.T3 + T4)

0.629

0.370-1.069

0.087

0.724

0.403-1.300

0.279

TNM stage (I + II vs. III + IV)

0.521

0.303-0.896

0.018**

0.433

0.239-0.786

0.006**

Lymphatic metastasis (No vs. Yes)

0.838

0.642-1.093

0.192

0.899

0.671-1.204

0.474

Regional lymph nodes (PN0+ PN1vs. PN2+ PN3)

0.584

0.332-1.024

0.061

0.575

0.310-1.065

0.078

Distant metastasis (No vs. Yes)

0.456

0.264-0.787

0.005**

0.432

0.231-0.811

0.009**

Expression of GAS5 (High vs. Low)

0.407

0.235-0.706

0.001**

0.591

0.436-0.803

0.001**

Multivariate analysis

      

TNM stage (I + II vs. III + IV)

0.631

0.357-1.115

0.113

0.537

0.289-1.000

0.049*

Distant metastasis (No vs. Yes)

0.384

0.123-1.197

0.099

0.381

0.105-1.389

0.144

Expression of GAS5 (High vs. Low)

0.466

0.263-0.828

0.009**

0.412

0.218-0.776

0.006**

  1. DFS, disease-free survival; OS, overall survival; HR, hazard ratio; 95% CI, 95% confidence interval. *P < 0.05 and **P < 0.01.
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BMC Cancer

ISSN: 1471-2407

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