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Table 3 Summary of mtDNA mutations in experimental mouse brain tumor cell linesa

From: Absence of pathogenic mitochondrial DNA mutations in mouse brain tumors

Brain tumor cell line

Metastatic

Host genetic background

Nucleotide position

Gene

DNA change

Stateb

Amino acid change

EPEN

-

B6

9829

Arg tRNA

InsAA

Homo

NAc

   

9461

ND3

T->C

Homo

Ile->Ile

CT-2A

-

B6

5182

OL

InsA

Homo

NA

VM-NM

-

VM

5182

OL

DelA

Homo

NA

   

15584

D-loop

T->C

Homo

NA

VM-M

+

VM

2159

16srRNA

A->G

Hetero

NA

  1. a Tumor cell lines mtDNA sequences were compared to host strain brain mtDNA populations
  2. b Homo, homoplasmy; hetero, heteroplasmy
  3. c NA, not applicable