No | Age/sex | Presenting symptoms/Onset of symptoms/Presence of constitutional symptoms | Performance status*/Physical findings | Cytological examination of peripheral blood | Cytological examination of bone marrow | Pathological examination of bone marrow |
---|---|---|---|---|---|---|
1 | 50/M | Back and chest pain/3 weeks/WL, F, NS | 3/Pallor, subicterus | MAHA, LEB | Dilute, not optimal, not diagnostic | Adenocarcinoma with signet ring cell features (Suggestion: primary focus should be searched in GI tract) |
2 | 40/M | Abdominal pain, failure to passage gas and stool by rectum, hematemesis/2 weeks/NS | 3/Ecchymoses, tenderness in epigastrium and lower-right quadrant | MAHA, LEB | Dilute, not optimal, not diagnostic | Adenocarcinoma |
3 | 41/F | Lumbar and extremity pain, lack of appetite, nausea/4 weeks/WL, F | 3/Pain with deep palpation of whole abdomen | LEB, MAHA | Dilute, not optimal, not diagnostic | Adenocarcinoma |
4 | 48/F | Lack of appetite, fatigue, nausea, vomiting, fever/2 months/F, WL | 3/A few ecchymoses | LEB | Dry tap; touch preparation is not optimal for evaluation | Indifferentiated carcinoma (only CK positive strongly) |
5 | 49/F | Dyspepsia, weakness/1 month/F | 3/Pallor, multiple ecchymoses, axillary single microLAP | LEB | Dense foreign cell infiltration forming groups (adenocarcinoma) | Adenocarcinoma |
6 | 71/M | Lumbar and leg pain, somnolence/20 days/- | 4/Pallor, impaired consciousness, dysorientation, dyscooperation, agitation | LEB | Dry tap; imprint: highly dense atypical somewhat large round or oval cells infiltration in clusters | Atypical epithelial cells in clusters (round cells infiltration) (Suggestion: Primary focus should be investigated in lungs) |
7 | 63/M | Cough, dysphagia, abdominal swelling, weakness, prominent loss in weight/WL, F, NS/1 month | 2/Scleral icterus, 5 cm hepatomegaly, melana in rectal digital palpation | LEB | Epithelioid cells in solid clusters (small cell carcinoma infiltration) | Small cell carcinoma |
8 | 57/F | Back, lumbar and leg pain, weakness, lack of appetite/3 months/WL | 3/Scleral icter, left axillary 2 cm LAP | MAHA, LEB | Infiltration with signet ring cells | Metastatic carcinoma (signet ring cell adenocarcinoma) |
9 | 45/M | Lumbar and leg pain, prominent loss in weight, generalized body pain/2 months/WL | 3/Pallor; | LEB | Infiltration with atypical large epithelioid cells | Metastatic carcinoma (Suggestion: Primary tumor should be investigated in prostate) |
10 | 25/F | Weakness, hip pain/6 months/ WL | 2/Pallor, right inguinal 2 cm LAP, 1 cm hepatomegaly, 2 cm splenomegaly | Rare blastic cells | Infiltration with blastic cells with vacuolated cytoplasm (MPO negative; flow: B and T cell markers negative) | Higly dense atypical cells in alveolar structure-actin, desmin and vimentin positive, LCA and CK negative-(metastatic alveolar rhabdomyosarcoma) |
11 | 35/M | Nausea, vomiting, prominent loss of weight, fatigue (alcohol, hashish and heroin dependence)/1 month/F, WL | 4/Pallor, cachexia | MAHA | Adenocarcinoma cell forming groups | Metastatic adenocarcinoma |
12 | 83/F | Prominent loss in weight, nausea, vomiting; backpain/6 months/WL | 3/Pallor; multipl ecchymoses | MAHA, LEB | Infiltration with signet ring cell carcinoma cells | Metastatic adenocarcinoma (signet ring cell carcinoma metastasis) |
13 | 61/F | Headache, sore throat, abdominal pain, constipation, nausea, vomiting (hematemesis and melana history), weakness/2 months/- | 2/Pallor and scleral icterus, pain with palpation of right hypochondrium | LEB | Dry tap in first 2 attempts and very dilute without particle in 3rd attempt. No atypical cells; imprint: technically inadequate | Metastatic carcinoma (CK positive atypical epithelioid cell infiltration, some of them in signet ring cell shape) |
14 | 75/M | Multiple ecchymoses on body and on extremities, purpura on lower extremities; hematuria/2 days/- | 1/Ecchymoses and purpura; 1.5 cm supraclavicular LAP | Only minimal shift to left; no erythroblast or poikilocytosis | Non-hematopoetic cell infiltration forming groups and some with mucineous character | Metastatic adenocarcinoma (CK+ cells forming glandular and tubular structures |
15 | 73/M | Confusion, adynamia/20 days/WL | 4/Hypotension, hypothermia, dehydration, scleral icterus, pallor, cachexia, 2 cm hepatomegaly | Slight shift to left, toxic granulation, slight poikilocytosis, no erythroblast, no fragmentation | Dilute and not optimal but there are nonhematopoietic cells in small groups like adenocarcinoma cells | Nondiagnostic in first report but adenocarcinoma metastasis reported after meticulous examination of new further sections of blocks |
16 | 75/F | Dyspnea, abdominal swelling/20 days/- | 4/Rales bilaterally, 2 cm hepatomegaly, pretibial edema, petechia in lower extremities | LEB, no poikilositosis or fragmentation | Atypical non-haematopoetic cells (adenocarcinoma metastasis) | ND |
17 | 68/M | Weakness, lack of appetite, prominent loss of weight, lumbar pain/3 months/WL | 1/Enlargement and nodulation in prostate in digital examination | LEB, slight poikilocytosis, no fragmentation | Infiltration with adenocarcinoma cells showing acinar and tubular structures | Metastatic carcinoma compatible with prostate carcinoma (PSA +) |
18 | 56/M | Pain in hips and legs, weakness/2 months/F, WL, SN | 2/Pallor, cachexia, multiple microLAPs in servical, axillary and inguinal regions, a few petechiae and eccyhymoses | LEB, MAHA | Infiltration with atypical epithelioid cells forming papillar and acinar structures (adenocarcinoma metastasis) | CK + PAS- adenocarcinoma metastasis (Suggestion: Primary focus should be investigated in prostate) |
19 | 45/M | Neck and hip pain, abdominal pain, weakness/ 1 month/WL | 3/restriction in physical activity | LEB, MAHA | Infiltration with adenocarcinoma cells | Metastatic adenocarcinoma; CK+ epithelioid cells, some of them mucinous and in shape of signet cell (Suggestion: Primary focus should be investigated in stomach) |