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Table 2 Summary of MMR studies in UUC

From: Low frequency of defective mismatch repair in a population-based series of upper urothelial carcinoma

Reference

Sex (male: female)

Median age total/MSI-H

Total no. of patients (renal pelvis/ureter/multifocal)

Fraction MSI-high

IHC loss

Hartmann et al.

2.2:1

66 / 62

73 (40/22/11)

0.21

0.87

Catto et al.

2.0:1

68 / 66

71 (44/25/2)

0.13

0.78

Blaszyk et al.

2.8:1

70 / -

114 (61/53/-)

0.31

ND

Roupert et al.

3.4:1#

- / 70

164 (ND)

0.16

0.6*

Amira et al.

1.6:1

68 / 72

24 (19/4/1)

0.25

ND

Ericson et al.

1.8:1

67 / 67

216 (154/60/2)

0.04

0.78

  1. * Only MSH2 assessed, ND: not determined
  2. #Applies to subset with MSI