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Figure 1 | BMC Cancer

Figure 1

From: JTE-522, a selective COX-2 inhibitor, inhibits growth of pulmonary metastases of colorectal cancer in rats

Figure 1

Graphs of pulmonary metastases of rats. (A) Lung weight of control and JTE-522 treated rats injected with RCN-9 (group 1, 10.70 ± 0.57 g; group 2, 9.14 ± 0.62 g; group 3, 5.61 ± 0.76 g; group 4, 3.52 ± 0.81 g). JTE-522 significantly and dose-dependently decreased the lung weight of each group (p = 0.0001). (B) Maximal diameter of metastatic tumors in control and JTE-522 treated rats injected with RCN-9 (group 1, 5067 ± 499 μm; group 2, 4233 ± 244 μm; group 3, 2583 ± 211 μm; group 4; 1990 ± 96 μm). JTE-522 significantly and dose-dependently decreased size of metastases (p = 0.0002). (C) The number of metastatic tumors in control and JTE-522 treated rats injected with RCN-9 (group 1, 203 ± 26; group 2, 197 ± 26; group 3, 204 ± 18; group 4, 165 ± 33). Microscopy shows no significant differences in the number of metastases (p = 0.13)

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