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Table 2 Results of Guthrie cards screening in patients with AML

From: Prenatal origin of childhood AML occurs less frequently than in childhood ALL

Patient

Molecular marker

Detection sensitivity

% blasts at diagnosis

Age at diagnosis

Guthrie card

AML1

FLT3/ITD

10-5

87%

2 y 9 mo

negative

AML2

FLT3/ITD

10-5

70%

8 y 9 mo

negative

 

PML/RARalpha

10-4-10-5

  

negative

AML3

PML/RARalpha

10-4-10-5

>80%

13 y 9 mo

negative

AML4

PML/RARalpha

10-4

55%

8 y 7 mo

negative

AML5

PML/RARalpha

10-4-10-5

64%

7 y 4 mo

negative

AML6

CBFbeta/MYH11

10-4-10-5

82%

5 y 8 mo

negative

AML7

CBFbeta/MYH11

10-4

70%

6 y 3 mo

negative

AML8

CBFbeta/MYH11

10-3-10-4

30%

2 y 6 mo

negative

AML9

MLL/AF6

10-4-10-5

73%

1 y 5 mo

negative

AML10

MLL/AF9

10-4-10-5

70%

1 y 7 mo

negative

AML11

MLL/AF10

10-4

78%

5 y 4 mo

negative

AML12

AML1/ETO

10-4-10-5

40%

9 y 4 mo

negative

AML13

AML1/ETO

10-3-10-4

5,2%

14 y 8 mo

negative