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Table 5 Estimated odds-ratios (ORs) and 95% confidence intervals (CIs) associated with the genotype combinations of the four significant two-way SNP-SNP interactions.

From: SNP-SNP interactions in breast cancer susceptibility

SNP-SNP interaction

SNP Genotypes

Cases n

Controls n

OR†

95% CI†

 

XPD

IL10

    

XPD-[Lys751Gln] and IL10-[G(-1082)A]

AA

AA

40

57

1.0

-

 

AC

AA

45

39

1.7

[0.9–2.7]

 

CC

AA

21

8

3.7

[1.6–9.7]

 

AA

AG

74

89

1.2

[0.8–1.9]

 

AC

AG

99

71

1.9

[1.3–3.1]

 

CC

AG

22

22

1.4

[0.8–3.1]

 

AA

GG

41

26

2.2

[1.3–3.9]

 

AC

GG

42

50

1.2

[0.7–2.4]

 

CC

GG

14

10

2.2

[0.8–5.5]

 

BARD1

XPD

    

BARD1-[Pro24Ser] and XPD-[Lys751Gln]

CC

AA

66

60

1.0

-

 

CT

AA

68

90

0.7

[0.4–1.1]

 

TT

AA

21

22

0.9

[0.4–1.8]

 

CC

AC

82

67

1.1

[0.7–1.8]

 

CT

AC

89

69

1.2

[0.7–1.9]

 

TT

AC

15

24

0.6

[0.3–1.2]

 

CC

CC

23

13

1.6

[0.7–3.4]

 

CT

CC

27

26

1.0

[0.5–1.9]

 

TT

CC

7

1

7.4

[1.3–12.4]

 

COMT

CCND1

    

COMT-[Met108/158Val] and CCND1-[Pro241Pro]

AA

GG

21

40

1.0

-

 

AG

GG

57

53

1.9

[1.3–4.6]

 

GG

GG

25

21

2.4

[1.0–4.9]

 

AA

AG

48

36

2.6

[1.3–4.5]

 

AG

AG

110

92

2.3

[1.3–4.5]

 

GG

AG

38

45

1.6

[1.0–3.2]

 

AA

AA

22

29

1.4

[0.7–3.3]

 

AG

AA

43

37

2.2

[1.1–4.3]

 

GG

AA

34

19

3.3

[1.9–7.2]

 

GSTP1

COMT

    

GSTP1-[Ile105Val] and COMT-[Met108/158Val]

AA

AA

30

49

1.0

-

 

AG

AA

46

48

1.5

[0.9–2.8]

 

GG

AA

15

8

3.4

[1.1–11.4]

 

AA

AG

95

92

1.7

[1.0–2.6]

 

AG

AG

91

69

2.2

[1.4–3.6]

 

GG

AG

24

21

1.8

[0.9–4.8]

 

AA

GG

54

36

2.6

[1.4–4.2]

 

AG

GG

36

41

1.5

[0.9–2.7]

 

GG

GG

7

8

1.6

[0.5–4.2]

  1. †OR and CIs estimated by bootstrap analysis in the 1,000 random samples.