Figure 3

Comparison of gene expression profiles among control C3H cells and M. fermentans infected cells at different stages of the malignant transformation. Gene expression in the cells was screened by the cDNA microarray technique. Expression profiles were generated by the analysis of the gene expression data using the computer software AtlasImage™ version 2.01. A comparison of these profiles was made among the control cells and infected cells. The graphs were plotted as the expression level at one stage over that at another stage for each of the 1185 genes examined. Correlation lines were plotted by the computer-fitting. The scales on both X- and Y-axis represent gene expression level using arbitrary density units of each dot. Panel A, Control cells vs. cells infected for 1 week (wk); Panel B, Control cells vs. cells infected for 11 weeks (wks); Panel C, Control cells vs. cells infected for 18 wks; Panel D, Cells infected for 1 wk vs. for 11 wks; Panel E, Cells infected for 1 wk vs. for 18 wks and Panel F, Cells infected for 11 wks vs. for 18 wks.