Table 1 IC50, ID50 and DEFs of the different cell lines. Sensitivity of different cell lines for gemcitabine (indicated by IC50 values) and radiotherapy (indicated by ID50 values) alone and the radiosensitising effect of gemcitabine represented by dose enhancement factors (DEF). (mean ± S.D.).
Cell line | IC50 (nM) | ID50 (Gy) | DEF 1 nM | DEF 2 nM | DEF 4 nM | DEF 6 nM | DEF 8 nM |
|---|---|---|---|---|---|---|---|
ECV304 | 3.05 ± 0.49 | 3.37 ± 0.40 | 1.37 ± 0.06 | 2.41 ± 0.24 | 3.21 ± 0.25 | 3.64 ± 0.40 | n.a. |
FaDu | 4.90 ± 0.46 | 3.09 ± 0.39 | 1.03 ± 0.04 | 1.22 ± 0.17 | 1.80 ± 0.26 | 2.37 ± 0.52 | n.a. |
H292 | 7.99 ± 0.77 | 4.00 ± 0.86 | 1.08 ± 0.10 | 1.23 ± 0.20 | 1.58 ± 0.22 | 2.07 ± 0.55 | 2.46 ± 0.82 |
A549 | 9.01 ± 0.89 | 4.51 ± 0.70 | 1.00 ± 0.04 | 1.21 ± 0.17 | 1.89 ± 0.51 | 2.39 ± 0.57 | 2.77 ± 0.26 |
CAL-27 | 8.92 ± 1.59 | 3.52 ± 0.88 | 1.06 ± 0.07 | 1.08 ± 0.04 | 1.49 ± 0.21 | 2.06 ± 0.06 | 2.51 ± 0.21 |
MCF-7 | 6.94 ± 2.03 | 4.96 ± 1.27 | 1.24 ± 0.06 | 1.45 ± 0.27 | 1.63 ± 0.13 | 2.55 ± 0.34 | n.a. |
HT-29 | 7.75 ± 1.61 | 5.64 ± 1.02 | 1.12 ± 0.21 | 1.30 ± 0.10 | 1.62 ± 0.04 | 2.39 ± 0.21 | n.a. |
Cell line | IC50 (nM) | ID50 (Gy) | DEF 7 nM | DEF 15 nM | DEF 35 nM | DEF 50 nM | DEF 100 nM |
Panc-1 | 77.8 ± 9.1 | 2.92 ± 0.35 | 1.20 ± 0.10 | 1.50 ± 0.19 | 1.55 ± 0.19 | 1.83 ± 0.20 | 1.56 ± 0.08 |