Figure 2From: Comparative evaluation of the treatment efficacy of suberoylanilide hydroxamic acid (SAHA) and paclitaxel in ovarian cancer cell lines and primary ovarian cancer cells from patientsEffect of SAHA and paclitaxel on caspase-3 activity in ovarian cancer cells. A, ovarian cancer cell lines; B, patient-derived ovarian cancer cells. Cells were incubated with SAHA or paclitaxel for 24 hours, and caspase-3 activity was measured using the fluorogenic substrate Ac-DEVD-AFC. Relative caspase-3 activities are the ratio of treated cells to untreated cells. Means ± SD of 1 (ASC-OC-2 SAHA), 2 (ASC-OC-1, ASC-OC-2 paclitaxel, ASC-OC-4), or 3 (ASC-OC-3, ASC-OC-5, cell lines) independent experiments are shown.Back to article page