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Table 3 Univariate and multivariate analyses for Metastasis-Free Survival

From: Prognostic significance of urokinase plasminogen activator and plasminogen activator inhibitor-1 mRNA expression in lymph node- and hormone receptor-positive breast cancer

Variable

Univariate

Multivariate

 

p-value

Hazard Ratio (95% CI)

p-value

Hazard Ratio (95% CI)

Tumor size

0.0002

1.03 (1.01–1.05)

  

T3 vs T1, T2

  

0.01

9.3 (1.49–58.04)

Lymph nodes

0.002

1.07 (1.02–1.13)

  

≥ 3 vs < 3

  

0.75

1.19 (0.39–3.56)

Age categories

0.08

2.08 (0.89–4.88)

  

≥ 50 years vs < 50 years

  

0.04

3.38 (1.05–10.87)

Histological Type

0.2

3.37 (0.45–24.83)

  

Ductal vs others

  

0.23

4.08 (0.39–42.23)

Histological grade

0.88

1.14 (0.65–2.01)

  

SBRII vs I

  

0.65

1.46 (0.27–7.7)

SBRIII vs I

  

0.6

1.6 (0.27–9.5)

uPA High vs Low

0.0005

1.14 (1.05–1.24)

0.62

1.31 (0.44–3.93)

PAI-1 High vs Low

<0.0001

5.56 (2.32–13.28)

0,0002

10.12 (3.03–33.76)

  1. Abbreviations: SBR, Scarff Bloom and Richardson.