Figure 2
From: Aberrant over-expression of a forkhead family member, FOXO1A, in a brain tumor cell line
a) The human FOXO1A locus. Genomic arrangement of the FOXO1A locus on chromosome 13q14.11, and position and sizes (3320 bp and 613 bp) of known EcoRI (E) restriction sites. b) Analysis of the PER-453 FOXO1A proximal promoter. The positions of seven putative GC-boxes (shaded squares), an FHBE (shaded triangle), and the single G to A base change identified in the FOXO1A promoter are indicated (see Table 3 for more details). c) Schematic depiction of the FOXO1A mRNA. The FOXO1A open reading frame of 1965 bp (thick line), forkhead DNA binding domain (dotted line), and the location of the cDNA probe used for Northern and Southern analysis (thin line) are indicated below the map.