Figure 6
Antitumor effect of the combined treatment with Zn(II)PPIX and/or chemotherapeutics. Mice were inoculated with 1 × 105 of C-26 or EMT6 cells or with 1 × 106 of B16F10 cells. On day 7 after inoculation of tumor cells mice received a single dose of chemotherapeutics: 50 mg/kg of 5-FU [A, D], 5 mg/kg of cisplatin [B, E] or 7.5 mg/kg of doxorubicin [C, F]. Zn(II)PPIX was administered i.p. for 7 consecutive days at a dose of 50 mg/kg [A-F]. Graphs show the influence of the treatment on the growth of tumors in mice [A-C] or on the change in mice weight as compared with initial weight. *P < 0.05 (two way Student's t-test) in comparison all other groups.