Figure 1

The representative experiment of tumor suppression and survival advantage in mice. Mice were treated i.p. with liposomal honokiol (25 mg/kg) every day for 21 days. In the combination treatment, liposomal honokiol is injected 4 hours later after cisplatin administration. (5 mg/kg, i.p. twice a week for two weeks). In addition, the control groups including PBS, liposome or cisplatin (5 mg/kg) alone. A, suppression of s.c. tumor growth in mice. The combination of liposomal honokiol with DDP can enhance the inhibition of the tumor growth. The results were expressed as the mean volume ± SD; B, a significant increase in survival in combined treatment mice compared with the controls. Liposomal honokiol plus cisplatin (solid square), liposomal honokiol (open triangle), cisplatin (solid triangle), liposome (open circles) and PBS (solid circle).