From: Expression profile of CREB knockdown in myeloid leukemia cells
Name | Location | Type | Drugs |
---|---|---|---|
Downregulated Cancer Genes | |||
ABCG2 | Plasma Membrane | transporter | Â |
ANG | Extracellular Space | enzyme | Â |
BCL2L11 | Cytoplasm | other | Â |
BECN1 | Cytoplasm | other | Â |
BMX | Cytoplasm | kinase | Â |
CA2 | Cytoplasm | enzyme | methazolamide, hydrochlorothiazide, acetazolamide, trichloromethiazide, dorzolamide, chlorothiazide, dorzolamide/timolol, brinzolamide, chlorthalidone, benzthiazide, sulfacetamide, topiramate |
CENPE | Nucleus | other | Â |
CNN1 | Cytoplasm | other | Â |
CREB1 | Nucleus | transcription regulator | Â |
CUL5 | Nucleus | ion channel | Â |
GFI1B | Nucleus | transcription regulator | Â |
KLF5 | Nucleus | transcription regulator | Â |
MDM2 (includes EG:4193) | Nucleus | transcription regulator | Â |
MPHOSPH1 | Nucleus | enzyme | Â |
MSH2 | Nucleus | enzyme | Â |
MVD | Cytoplasm | enzyme | Â |
NR4A3 | Nucleus | ligand-dependent nuclear receptor | Â |
NUMB | Plasma Membrane | other | Â |
PPP1R2 | Cytoplasm | phosphatase | Â |
PTGS2 | Cytoplasm | enzyme | acetaminophen/pentazocine, acetaminophen/clemastine/pseudoephedrine, aspirin/butalbital/caffeine, |
RB1CC1 | Nucleus | other | Â |
SILV | Plasma Membrane | enzyme | Â |
SMC2 | Nucleus | transporter | Â |
SMC3 | Nucleus | other | Â |
TFDP2 | Nucleus | transcription regulator | Â |
THRB | Nucleus | ligand-dependent nuclear receptor | 3,5-diiodothyropropionic acid, amiodarone, thyroxine, L-triiodothyronine |
UBE2B | Cytoplasm | enzyme | Â |
VRK1 | Nucleus | kinase | Â |
WWOX | Cytoplasm | enzyme | Â |
Upregulated cancer Genes | Â | Â | Â |
ACOX1 | Cytoplasm | enzyme | Â |
ARID1A | Nucleus | transcription regulator | Â |
BCL6 | Nucleus | transcription regulator | Â |
BDKRB2 | Plasma Membrane | G-protein coupled receptor | anatibant, icatibant |
CD44 | Plasma Membrane | other | Â |
CDKN1A | Nucleus | kinase | Â |
COL15A1 | Extracellular Space | other | collagenase |
CREM | Nucleus | transcription regulator | Â |
CRKL | Cytoplasm | kinase | Â |
DCLRE1C | Nucleus | enzyme | Â |
DEGS1 | Plasma Membrane | enzyme | Â |
DIAPH1 | Cytoplasm | other | Â |
DUSP1 | Nucleus | phosphatase | Â |
EGR2 | Nucleus | transcription regulator | Â |
ELK1 | Nucleus | transcription regulator | Â |
ENC1 | Nucleus | peptidase | Â |
F2R | Plasma Membrane | G-protein coupled receptor | chrysalin, argatroban, bivalirudin |
FOSL1 | Nucleus | transcription regulator | Â |
HIP1 | Cytoplasm | other | Â |
HSPG2 (includes EG:3339) | Plasma Membrane | other | Â |
ICAM1 | Plasma Membrane | transmembrane receptor | Â |
ID1 | Nucleus | transcription regulator | Â |
IL6 | Extracellular Space | cytokine | tocilizumab |
IL1R1 | Plasma Membrane | transmembrane receptor | anakinra |
IL6ST | Plasma Membrane | transmembrane receptor | Â |
ITGA5 | Plasma Membrane | other | Â |
KIF14 | Cytoplasm | other | Â |
METAP2 | Cytoplasm | peptidase | PPI-2458 |
NCOA3 | Nucleus | transcription regulator | Â |
NDRG1 | Nucleus | kinase | Â |
PHLDA1 | Cytoplasm | other | Â |
PLAT | Extracellular Space | peptidase | Â |
RASSF1 | Nucleus | other | Â |
RBL1 | Nucleus | other | Â |
REL | Nucleus | transcription regulator | Â |
RHOB | Cytoplasm | enzyme | Â |
SERPINB9 | Cytoplasm | other | Â |
SUFU | Nucleus | transcription regulator | Â |
TIMP1 | Extracellular Space | other | Â |
TNFRSF21 | Plasma Membrane | other | Â |
USP2 | Cytoplasm | peptidase | Â |