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Table 3 The subset of CREB target genes associated with cancer according to Ingenuity Pathways Analysis.

From: Expression profile of CREB knockdown in myeloid leukemia cells

Name

Location

Type

Drugs

Downregulated Cancer Genes

ABCG2

Plasma Membrane

transporter

 

ANG

Extracellular Space

enzyme

 

BCL2L11

Cytoplasm

other

 

BECN1

Cytoplasm

other

 

BMX

Cytoplasm

kinase

 

CA2

Cytoplasm

enzyme

methazolamide, hydrochlorothiazide, acetazolamide, trichloromethiazide, dorzolamide, chlorothiazide, dorzolamide/timolol, brinzolamide, chlorthalidone, benzthiazide, sulfacetamide, topiramate

CENPE

Nucleus

other

 

CNN1

Cytoplasm

other

 

CREB1

Nucleus

transcription regulator

 

CUL5

Nucleus

ion channel

 

GFI1B

Nucleus

transcription regulator

 

KLF5

Nucleus

transcription regulator

 

MDM2 (includes EG:4193)

Nucleus

transcription regulator

 

MPHOSPH1

Nucleus

enzyme

 

MSH2

Nucleus

enzyme

 

MVD

Cytoplasm

enzyme

 

NR4A3

Nucleus

ligand-dependent nuclear receptor

 

NUMB

Plasma Membrane

other

 

PPP1R2

Cytoplasm

phosphatase

 

PTGS2

Cytoplasm

enzyme

acetaminophen/pentazocine, acetaminophen/clemastine/pseudoephedrine, aspirin/butalbital/caffeine,

RB1CC1

Nucleus

other

 

SILV

Plasma Membrane

enzyme

 

SMC2

Nucleus

transporter

 

SMC3

Nucleus

other

 

TFDP2

Nucleus

transcription regulator

 

THRB

Nucleus

ligand-dependent nuclear receptor

3,5-diiodothyropropionic acid, amiodarone, thyroxine, L-triiodothyronine

UBE2B

Cytoplasm

enzyme

 

VRK1

Nucleus

kinase

 

WWOX

Cytoplasm

enzyme

 

Upregulated cancer Genes

   

ACOX1

Cytoplasm

enzyme

 

ARID1A

Nucleus

transcription regulator

 

BCL6

Nucleus

transcription regulator

 

BDKRB2

Plasma Membrane

G-protein coupled receptor

anatibant, icatibant

CD44

Plasma Membrane

other

 

CDKN1A

Nucleus

kinase

 

COL15A1

Extracellular Space

other

collagenase

CREM

Nucleus

transcription regulator

 

CRKL

Cytoplasm

kinase

 

DCLRE1C

Nucleus

enzyme

 

DEGS1

Plasma Membrane

enzyme

 

DIAPH1

Cytoplasm

other

 

DUSP1

Nucleus

phosphatase

 

EGR2

Nucleus

transcription regulator

 

ELK1

Nucleus

transcription regulator

 

ENC1

Nucleus

peptidase

 

F2R

Plasma Membrane

G-protein coupled receptor

chrysalin, argatroban, bivalirudin

FOSL1

Nucleus

transcription regulator

 

HIP1

Cytoplasm

other

 

HSPG2 (includes EG:3339)

Plasma Membrane

other

 

ICAM1

Plasma Membrane

transmembrane receptor

 

ID1

Nucleus

transcription regulator

 

IL6

Extracellular Space

cytokine

tocilizumab

IL1R1

Plasma Membrane

transmembrane receptor

anakinra

IL6ST

Plasma Membrane

transmembrane receptor

 

ITGA5

Plasma Membrane

other

 

KIF14

Cytoplasm

other

 

METAP2

Cytoplasm

peptidase

PPI-2458

NCOA3

Nucleus

transcription regulator

 

NDRG1

Nucleus

kinase

 

PHLDA1

Cytoplasm

other

 

PLAT

Extracellular Space

peptidase

 

RASSF1

Nucleus

other

 

RBL1

Nucleus

other

 

REL

Nucleus

transcription regulator

 

RHOB

Cytoplasm

enzyme

 

SERPINB9

Cytoplasm

other

 

SUFU

Nucleus

transcription regulator

 

TIMP1

Extracellular Space

other

 

TNFRSF21

Plasma Membrane

other

 

USP2

Cytoplasm

peptidase

 
  1. Column 1 is the gene name, column 2 the localization, column 3 is a description of the protein function and column 4 are compounds that target the protein.