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Table 4 Univariate and multivariate analyses of prognosis using pathological factors and biomarkers of primary breast cancer

From: Expression of centromere protein F (CENP-F) associated with higher FDG uptake on PET/CT, detected by cDNA microarray, predicts high-risk patients with primary breast cancer

  Disease-free survival
Variable Univariate Multivariate
  HR 95% CI p-value HR 95% CI p-value
Tumor size (2 cm vs <2 cm) 6.7 2.68–16.72 <0.0001 4.49 1.56–12.74 0.0047
Nodal status (+ vs -) 4.79 2.73–8.38 <0.0001 4.1 2.18–7.74 <0.0001
Nuclear grade (Grade 3 vs 1–2) 3.96 2.32–6.76 <0.0001 1.69 0.92–3.13 0.094
CENP-F (positive vs negative) 3.92 2.19–7.03 <0.0001 2.94 1.51–5.72 0.0015
p53 (positive vs negative) 2.35 1.36–4.09 0.0024 1.38 0.75–2.52 0.3
Ki67 (10% vs 10% >) 2.25 1.36–3.72 0.0016 2.05 1.18–3.56 0.011
HER2 (3+,FISH+ vs 0,1+,2+(FISH-)) 2.11 1.07–4.16 0.031 1.79 0.84–3.8 0.13
ER (positive vs negative) 1.54 0.94–2.52 0.087   n/a  
  Overall survival
  Univariate Multivariate
Variable HR 95% CI p-value HR 95% CI p-value
Nodal status (+ vs -) 9.83 2.58–15.71 0.0041 11.88 1.45–97.09 0.021
Nuclear grade (Grade 3 vs 1–2) 3.73 1.25–11.15 0.0019 2.51 0.72–8.04 0.15
CENP-F (positive vs negative) 3.35 1.05–10.72 0.042 2.05 0.52–8.09 0.31
Tumor size (2 cm vs <2 cm) 2.28 1.3–3.99 0.0039 1.37 0.72–2.64 0.34
HER2 (3+,FISH+ vs 0,1+,2+(FISH-)) 3.02 0.84–10.85 0.09   n/a  
Ki67 (10% vs 10% >) 2.22 0.78–6.36 0.13   n/a  
p53 (positive vs negative) 1.71 0.48–6.13 0.41   n/a  
ER (positive vs negative) 1.26 0.44–3.62 0.67   n/a  
  1. Abbreviations; HR, hazard ratio; CI, confidence interval; vs, versus; n/a, not applicable; positive, strong staining (2+) in 10% of cancer cells;negative, others