Figure 5
From: Chondromodulin-1 directly suppresses growth of human cancer cells
ChM1 modulates the STAT pathway. The effect of ChM1 on signal transduction pathways analyzed using a luciferase assay. ChM1 inhibited transcriptional activation through the STAT-luc by 30% in HepG2 and HeLa cells and by 40% in HUVECs. ChM1 inhibited transcriptional activation through the GAS-luc by 40% in HepG2 and HeLa cells and by 60% in HUVECs. In contrast, ChM1 did not affect transcriptional activity through the ISRE-luc in these cell lines. Each column and bar represent a mean and SD (n = 4). (*: p < 0.05; **: p < 0.001).