Mammographic density and epithelial histopathologic markers

BMC Cancer

Table 2 Marker expression and mammographic density by ethnicity

Marker		All women (n = 159)			Caucasian (n = 49)			Japanese (n = 70)
		Category*			Category			Category
		1	2	P-value	1	2	P-value	1	2	P-value
ERα	% density^†	36.9	35.6	0.75	39.8	23.9	0.04	38.8	44.5	0.39
	Dense area^#	33.7	33.6	0.98	38.2	26.2	0.18	33.8	38.0	0.50
	Number	122	35		38	11		53	16
ERβ	% density	35.8	38.2	0.49	33.8	45.4	0.05	40.2	39.1	0.85
	Dense area	33.0	34.6	0.66	34.4	40.9	0.38	35.2	33.3	0.74
	Number	110	47		36	13		47	21
PR	% density	34.9	38.3	0.28	35.3	41.0	0.30	37.5	41.0	0.57
	Dense area	30.6	36.4	0.09	31.1	45.9	0.03	35.2	34.4	0.90
	Number	77	81		23	25		35	35
HER2/neu	% density	37.1	36.3	0.82	35.7	40.9	0.38	41.3	37.9	0.57
	Dense area	34.4	33.2	0.74	36.4	36.5	0.99	35.5	33.6	0.73
	Number	104	52		34	15		45	23
Ki-67	% density	34.3	37.7	0.32	35.5	39.3	0.53	36.8	41.2	0.46
	Dense area	32.9	33.5	0.87	38.7	34.9	0.60	32.8	35.3	0.66
	Number	65	90		16	32		31	39
PCNA	% density	36.0	38.2	0.50	37.7	37.1	0.91	38.7	42.2	0.52
	Dense area	33.4	33.7	0.94	36.7	36.4	0.97	35.1	33.9	0.82
	Number	95	63		28	20		42	28

* Categories for ERα, ERβ, HER2/neu and PCNA; category 1 <10% staining, category 2 ≥ 10% staining. Categories for PR and Ki-67; category 1 = no staining, category 2 = any staining
^† Mean percent breast density
^# Mean dense area in cm²
Mean values and p-values calculated using general linear models adjusted for age at mammogram, BMI, ethnicity, HT use at mammogram, menopausal status, parity, age at first live birth, age at menarche and family history of breast cancer.
(ERα = estrogen receptor alpha; ERβ = estrogen receptor beta; PR = progesterone receptor; HER2/neu = Human Epidermal growth factor receptor2; PCNA = Proliferating Cell Nuclear Antigen; BMI = body mass index)

ISSN: 1471-2407