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Table 4 HPV detection and typing of 15 HNSCC and 3 RRP patients.

From: Sensitive HPV detection in oropharyngeal cancers

   

HPV detection method

Patient

Age

Diagnosis

PGMY 09/11

Linear Array

GP5+/GP6+ nest

1

52

SCC

-

-

HPV 6

2

46

SCC

-

-

HPV 6

3

49

SCC

-

-

HPV 16, mixed

4

58

RRP

-

-

-

5

68

SCC

-

HPV 16

HPV 16

6

31

RRP

HPV 11

HPV 11

HPV 11

7

61

SCC

-

-

-

8

68

SCC

-

-

-

9

54

SCC

-

HPV 16

HPV 6

10

64

SCC

-

-

HPV 6

11

72

SCC

-

-

HPV 16

12

73

SCC

-

HPV 11

HPV 6

13

87

RRP

-

-

-

14

69

SCC

-

-

-

15

74

SCC

-

-

-

16

50

SCC

-

-

HPV 40

17

78

SCC

-

-

mixed types

18

74

SCC

-

-

-

HPV +ve HNSCC detection

0/15

3/15

10/15

  1. PCR detection, using the PGMY09/11 primer set was unable to detect the presence of HPV in any of the head and neck squamous cell carcinoma (SCC) samples (0/15). Improved detection was achieved using the Linear Array assay (3/15) and following a nested PCR of the PGMY reaction with the GP5+/GP6+ primer set (10/15). HPV was only detected in 1/3 of recurrent respiratory papillomatosis (RRP) samples, irrespective of the method used. Samples were scored as positive if HPV was detected using one or more of the methods employed.
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BMC Cancer

ISSN: 1471-2407

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