Figure 1

Resveratrol inhibited the metastasis of colorectal cancer LoVo cells in vitro and in vivo imaging by tail vein injection. (A) Correlation of resveratrol drug concnetrations (0, 6.25, 12.5, 25, 50, 100, 200 μM) and cell viability in LoVo cells for 48 h and 72 h. (B) LoVo-pLV4-GFP cells were respectively injected into the lateral tail vein. One week later, resveratrol was administrated with the concentration of 0, 50 mg/Kg, 100 mg/Kg, 150 mg/Kg every day for 3 weeks. Seven weeks later, the established lungs metastases images were observed by LB983 NIGHTOWL II system. (C) The organs of lung were excised, and the metastasis was checked by hemaoxylin-eosin staining, and the numbers of metastatic lesions were counted. **P < 0.01, compared with LoVo-pLV4-GFP cells without treatment of resveratrol.