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Figure 5 | BMC Cancer

Figure 5

From: Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expression

Figure 5

Resveratrol repressed expressions of EMT-induced transcription factors and Smads signaling pathway. Whole or cell extracts of different cellular compartments from LoVo cells were probed for (A) Slug Snail, ZEB1, Twist, and (B) p-Smad2/3, Smad2/3. **P < 0.01, compared with group without treatment of TGF-β1 and resveratrol. (C) LoVo cells treated with TGF-β1 or (and) TGFβRI/II inhibitor (LY2109761) were analyzed for the Snail and E-cadherin mRNA expression by RT-PCR, GAPDH was chosen as a control. (D) Whole or cell extracts of different cellular compartments from LoVo cells were probed for p-Smad2/3, Smad2/3, Snail and E-cadherin expression. **P < 0.01, compared with group without treatment of TGF-β1 and LY2109761.

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BMC Cancer

ISSN: 1471-2407

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