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Table 1 Top twenty up- and down-regulated genes by cisplatin in MCF7 cells

From: Role of the splicing factor SRSF4 in cisplatin-induced modifications of pre-mRNA splicing and apoptosis

Gene

Name

Fold_change

q_value

SERPINB5

serpin peptidase inhibitor, Clade B (Ovalbumin), member 5

126

1.54E-08

POU3F1

POU class 3 homeobox 1

105

6.15E-03

NKX1-2

NK1 homeobox 2

75

3.63E-02

LAMP3

lysosomal-associated membrane protein 3

63

2.28E-02

ATF3

activating transcription factor 3

51

3.58E-07

GADD45A

growth arrest and DNA-damage-inducible, alpha

51

1.51E-07

HBEGF

heparin-binding EGF-like growth factor

44

8.31E-06

HES2

hairy and enhancer of split 2 (Drosophila)

41

3.59E-05

NGFR

nerve growth factor receptor

41

4.80E-04

SNAI1

snail family zinc finger 1

32

1.82E-03

GPR3

G protein-coupled receptor 3

32

4.17E-03

GPR172B

solute carrier family 52, riboflavin transporter, member 1

29

2.38E-03

PTAFR

platelet-activating factor receptor

28

2.45E-04

PRODH

proline dehydrogenase (oxidase) 1

27

2.92E-02

C5orf4

chromosome 13 open reading frame, human

27

2.07E-03

PMAIP1

phorbol-12-myristate-13-acetate-induced protein 1

22

1.26E-06

HAP1

huntingtin-associated protein 1

21

3.08E-02

FAS

TNF receptor superfamily member 6

21

4.92E-05

GUCA1B

guanylate cyclase activator 1B (retina)

20

4.71E-03

LIF

leukemia inhibitory factor

19

5.31E-05

ROBO1

roundabout, axon guidance receptor, homolog 1

−46

2.45E-06

NEGR1

neuronal growth regulator 1

−48

7.78E-04

EYA4

eyes absent homolog 4

−49

3.90E-03

CADPS2

Ca++ − dependent secretion activator 2

−49

7.97E-03

SLCO3A1

solute carrier organic anion transporter family, member 3A1

−49

3.07E-02

SAMD12

sterile alpha motif domain containing 12

−50

4.74E-04

NFIA

nuclear factor I/A

−53

2.38E-04

SULF1

sulfatase 1

−55

6.43E-04

MAGI1

membrane associated guanylate kinase, WW and PDZ domain containing 1

−56

5.79E-05

HS6ST3

heparan sulfate 6-O-sulfotransferase 3

−62

1.80E-04

PLCH1

phospholipase C, eta 1

−62

2.47E-03

PPP1R9A

protein phosphatase 1, regulatory subunit 9A

−67

1.24E-03

KCNJ8

potassium inwardly-rectifying channel, subfamily J, member 8

−67

3.33E-04

MLLT3

myeloid/lymphoid or mixed-lineage leukemia translocated to, 3

−67

1.50E-02

PLXDC2

plexin domain containing 2

−70

2.52E-04

SEMA5A

semaphorin 5A

−75

1.50E-04

ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

−81

7.36E-04

LTBP1

latent transforming growth factor beta binding protein 1

−94

3.39E-05

TIAM1

T-cell lymphoma invasion and metastasis 1

−146

8.42E-03

GPHN

Gephyrin

−159

3.85E-05

  1. Fold change expression in cisplatin-treated (50 μM, 24 hours) samples relative to control and q-values as measured by RNA-seq are indicated.