Figure 2

Interactive network of the proteins that are differentially expressed in prostate cancer as compared to BPH. The network node and edges represent proteins and their interactions respectively. The intensity of the node color indicates the degree of up-regulation (red) or down-regulation (green), while white nodes indicate non-modified proteins that may be affected by post-translational modification. All networks shown were significantly affected in prostate cancer, with a score >15. The network analysis identified many focus hubs (e.g. NFκB, ERK1/2, Collagen, TGFβ, PI3K, p38 MAPK) with high degree of interactions.