Table 1 Patient characteristics
SNAI2 median | |||||
|---|---|---|---|---|---|
Characteristic | Total (n = 49) | Low (%) | High (%) | p-value | |
Age | |||||
Median (Range) | 66(39–82) | 66(39–82) | 66(51–75) | ||
Gender | |||||
Female | 23 | 11 | 12 | 0.778 | |
Male | 26 | 14 | 12 | ||
ECOG PS | |||||
Median | 1 | ||||
0-1 | 43 | 23 | 20 | 0.417 | |
2 | 6 | 2 | 4 | ||
Histology | |||||
Adeno | 31 | 13 | 18 | 0.345 | |
Squamous cell | 14 | 9 | 5 | ||
other | 4 | 3 | 1 | ||
No. of organs involved | |||||
Median | |||||
≤1 | 19 | 10 | 9 | n.s. | |
2 | 18 | 9 | 9 | n.s. | |
≥3 | 12 | 6 | 6 | n.s. | |
Stage | |||||
IIIB / IIIA | 2 | 0 | 2 | 0.235 | |
IV | 47 | 25 | 22 | ||
Treatment | |||||
Arm A (Cisplatin/Docetaxel) | 23 | 13 | 10 | 0.571 | |
Arm B (Oxaliplatin/Docetaxel) | 26 | 12 | 14 | ||
ESR1 status | |||||
ESR1 high | 25 | 24 | 1 | <0.0001 | |
ESR1 low | 24 | 1 | 23 | ||