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Table 1 Summary of demographic characteristics of HNCSS patients and acetyl- and butyrylcholinesterase activity in upper respiratory epithelium

From: Dysregulated cholinergic network as a novel biomarker of poor prognostic in patients with head and neck squamous cell carcinoma

  

AChE activity (mU/mg protein)

BChE activity (mU/mg protein)

Samples

N

ANCT

Tumour

P-value

ANCT

Tumour

P-value

Total

57

5.416 ± 0.501

3.584 ± 0.633

0.002

6.350 ± 0.599

3.965 ± 0.423

<0.001

Gender

       

Male

53

5.094 ± 0.473

3.525 ± 0.674

0.003

6.278 ± 0.638

3.952 ± 0.450

0.001

Female

4

9.680 ± 2.962

4.363 ± 1.395

0.273

5.730 ± 1.303

3.142 ± 0.843

0.068

Age

       

<60

18

6.175 ± 0.929

4.553 ± 1.390

0.145

7.007 ± 1.311

4.572 ± 0.808

0.093

>60

39

5.066 ± 0.593

3.136 ± 0.669

0.005

5.891 ± 0.648

3.825 ± 0.495

0.002

Tobacco

       

Non-smoker

5

4.978 ± 1.556

3.135 ± 1.820

0.225

3.891 ± 0.876

3.657 ± 0.922

0.893

Smoker

46

5.145 ± 0.510

3.721 ± 0.741

0.017

6.852 ± 0.716

3.872 ± 0.431

<0.001

Alcohol

       

No

17

5.219 ± 0.621

3.524 ± 0.695

0.290

5.807 ± 1.034

4.701 ± 0.645

0.650

Yes

16

5.921 ± 0.822

3.737 ± 1.425

0.034

6.491 ± 0.745

3.746 ± 0.445

<0.001

Location

       

Glottic

29

4.736 ± 0.663

3.467 ± 0.902

0.003

5.978 ± 0.794

3.612 ± 0.697

0.004

Supraglottic

21

5.200 ± 0.607

4.423 ± 1.201

0.017

7.593 ± 1.205

4.299 ± 0.603

0.007

Other

7

8.374 ± 1.699

2.699 ± 0.692

0.052

4.544 ± 0.530

4.362 ± 0.843

1.000

Differentiation

       

Well

17

5.279 ± 0.828

4.057 ± 1.473

0.227

5.013 ± 0.806

3.771 ± 0.828

0.193

Moderate/Poor

32

5.123 ± 0.637

3.631 ± 0.807

0.030

7.684 ± 0.947

4.334 ± 0.622

0.002

Clinical Stage

       

Stage I + II

19

4.660 ± 0.717

2.638 ± 0.714

0.059

6.118 ± 0.849

4.046 ± 0.858

0.058

Stage III + IV

36

5.319 ± 0.598

4.167 ± 0.921

0.033

6.568 ± 0.829

3.951 ± 0.504

0.002

Nodal Status

       

N0

30

4.780 ± 0.530

3.231 ± 0.754

0.077

6.438 ± 0.857

3.624 ± 0.534

0.003

N+

19

5.301 ± 0.943

3.432 ± 1.335

0.032

6.644 ± 1.006

4.878 ± 0.838

0.039

T Stage

       

T1

4

4.707 ± 1.638

1.405 ± 0.670

0.068

4.456 ± 0.583

2.228 ± 0.367

0.068

T2

16

4.485 ± 0.790

2.893 ± 0.822

0.179

7.293 ± 1.302

4.265 ± 0.952

0.063

T3

24

5.727 ± 1.178

4.600 ± 1.562

0.382

6.522 ± 1.681

3.815 ± 0.559

0.110

T4

11

5.224 ± 0.692

4.019 ± 1.214

0.031

6.085 ± 0.853

4.331 ± 0.756

0.028

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BMC Cancer

ISSN: 1471-2407

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