Skip to main content
Fig. 8 | BMC Cancer

Fig. 8

From: A potential small-molecule synthetic antilymphangiogenic agent norcantharidin inhibits tumor growth and lymphangiogenesis of human colonic adenocarcinomas through blocking VEGF-A,-C,-D/VEGFR-2,-3 “multi-points priming” mechanisms in vitro and in vivo

Fig. 8

The expression of VEGF-A, VEGF-C, VEGF-D, VEGFR-2 and VEGFR-3 protein products of HCACCs and the co-culture system of each group and the effect of NCTD on expression of these protein products in vitro (S-P staining, magnification × 200). a The expression of VEGF-A, VEGF-C, VEGF-D, VEGFR-2 and VEGFR-3 protein products of HCACCs and the co-culture system of each group. The expression of VEGF-C, VEGF-D and VEGFR-3 protein products (brown staining in cytoplasm) of the co-culture system was higher than those of alone HCACC culture (*P = 0.001); but there is no difference on the expression of VEGF-A and VEGFR-2 protein products between alone HCACC culture and the co-culture system. b The inhibitory effect of NCTD on expression of these protein products of the co-culture system. The expression of VEGF-C, VEGF-D and VEGFR-3 protein products in NCTD, mF4-31C1 or NCTD + mF4-31C1 group was downregulated significantly as compared to control group (*P < 0.01), and the expression of these proteins in NCTD + mF4-31C1 group was lower than that of NCTD or mF4-31C1 group (#P < 0.05); whereas the expression of VEGF-A and VEGFR-2 protein products in NCTD or NCTD + mF4-31C1 group was downregulated significantly as compared to control or mF4-31C1 group (*P < 0.01), but no difference on VEGF-A and VEGFR-2 expression between control group and mF4-31C1 group

Back to article page