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Table 6 Pathway analysis of genetic changes in the ‘hypoxic only’ response to cisplatin in A2780 and A2780cis

From: Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer

Cell Line

Pathway

P-value

Change in Expression

A2780

Apoptosis

0.001

Up-regulated

ABC Transporters

0.002

Amyotrophic Lateral Sclerosis

0.005

Small Cell Lung Cancer

0.02

p53 signalling

0.02

Pancreatic Cancer

0.02

Chronic Myeloid Leukemia

0.03

A2780cis

Focal Adhesion

0.04

A2780

Systemic Lupus Erythematosus

0.02

Down-regulated

MAPK signalling

<0.001

Cell Cycle

0.002

Steroid Biosynthesis

0.005

ErbB Signalling

0.01

Nitrogen Metabolism

0.02

Axon Guidance

0.02

Colorectal Cancer

0.03

Gap Junction

0.04

A2780cis

Systemic Lupus Erythematosus

<0.001

Valine, Leucine and Isoleucine degradation

0.004

Homologous Recombination

0.03

Oocyte meiosis

0.05