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Table 1 Study protocols and included patient numbers

From: Impact of delays in initiating postoperative chemoradiation while determining the MGMT promoter-methylation statuses of patients with primary glioblastoma

Designs of the analyzed prospective studies

Study

Phase

Treatment regimens

MGMT promoter status

Absolut patient numbers

TEMSIROLIMUS (EORTC 26082–22081)

III

1. Conventional RT with 60 Gy plus temsirolimus 25 mg once a week beginning 7 days before initiation of radiotherapy. Adjuvant cycles of temsirolimus 25 mg once a week until progression.

Unmethylated

19

2. Conventional RT with 60 Gy plus 75 mg/m2/d TMZ during RT. Up to six cycles of adjuvant TMZ for 5 days every 28 days with 150 mg/m2/d for the first adjuvant cycle and 200 mg/m2/d for the following cycles.

ENZASTAURIN (H6Q-MC-S039)

II

1. Conventional RT with 60 Gy plus Enzastaurin 250 mg b.i.d. until progression or a maximum of 3 years.

Unmethylated

13

2. Conventional RT with 60 Gy plus 75 mg/m2/d TMZ during RT. Up to six cycles of adjuvant TMZ for 5 days every 28 days with 150 mg/m2/d for the first adjuvant cycle and 200 mg/m2 for the following cycles.

CENTRIC (EORTC 26071–22072)

III

1. Conventional RT with 60 Gy plus 75 mg/m2/d TMZ during RT plus Cilengitide 2000 mg twice a week beginning 7 days before initiation of radiotherapy until day 77 or progression. Up to six cycles of adjuvant TMZ for 5 days every 28 days with 150 mg/m2/d for the first adjuvant cycle and 200 mg/m2/d for the following cycles.

Methylated

18

2. Conventional RT with 60 Gy plus 75 mg/m2/d TMZ during RT. Up to six cycles of adjuvant TMZ for 5 days every 28 days with 150 mg/m2/d for the first adjuvant cycle and 200 mg/m2/d for the following cycles.

  1. Abbreviations: MGMT = O6-methylguanine-DNA methyltransferase; TMZ = Temozolomide; mg = Milligram; m = Meter; d = Day, RT = Radiation Therapy