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Table 2 Univariable and multivariable analysis of overall and cancer-specific survival

From: Population-based SEER trend analysis of overall and cancer-specific survival in 5138 patients with gastrointestinal stromal tumor

  

Overall survival

Cancer-specific survival

Covariates

 

Unadjusted a

Cox regression, full model b

Unadjusted a

Cox regression, full model b

  

HR (95 % CI)

p c)

HR (95 % CI)

p c)

HR (95 % CI)

p c)

HR (95 % CI)

p c)

Location

Stomach

Reference

<0.001

Reference

0.002

Reference

<0.001

Reference

<0.001

 

Small intestine

0.87 (0.78–0.97)

 

0.98 (0.87–1.10)

 

0.90 (0.78–1.03)

 

0.96 (0.83–1.11)

 
 

Other

1.31 (1.13–1.53)

 

1.30 (1.12–1.52)

 

1.54 (1.30–1.84)

 

1.46 (1.22–1.74)

 

Size

<5 cm

Reference

<0.001

Reference

<0.001

Reference

<0.001

Reference

<0.001

 

5 cm–9.9 cm

1.13 (0.97–1.32)

 

1.04 (0.89–1.21)

 

1.52 (1.23–1.89)

 

1.38 (1.12–1.72)

 
 

10 cm+

1.94 (1.68–2.25)

 

1.63 (1.40–1.89)

 

3.15 (2.58–3.85)

 

2.52 (2.05–3.08)

 
 

Unknown

2.36 (2.01–2.78)

 

1.49 (1.25–1.78)

 

3.72 (2.99–4.62)

 

2.00 (1.58–2.52)

 

Metastatic disease

M0

Reference

<0.001

Reference

<0.001

Reference

<0.001

Reference

<0.001

 

M1

2.84 (2.56–3.16)

 

2.03 (1.80–2.28)

 

3.69 (3.26–4.17)

 

2.42 (2.11–2.78)

 

N stage

N−

Reference

<0.001

Reference

0.001

Reference

<0.001

Reference

0.001

 

N+

2.28 (1.89–2.74)

 

1.47 (1.21–1.79)

 

2.73 (2.20–3.38)

 

1.55 (1.24–1.93)

 
 

NX

1.83 (1.63–2.05)

 

1.09 (0.96–1.24)

 

2.12 (1.85–2.42)

 

1.16 (1.00–1.36)

 

Surgery of the

No surgery primary

Reference

<0.001

Reference

<0.001

Reference

<0.001

Reference

<0.001

primary

Surgery primary

0.33 (0.29–0.36)

 

0.49 (0.43–0.56)

 

0.27 (0.24–0.31)

 

0.44 (0.38–0.52)

 
 

Unknown

0.87 (0.36–2.09)

 

1.36 (0.56–3.31)

 

0.90 (0.34–2.42)

 

1.36 (0.50–3.67)

 

Year

1998 to 2002

Reference

<0.001

Reference

<0.001

Reference

<0.001

Reference

<0.001

 

2003 to 2005

0.79 (0.70–0.90)

 

0.76 (0.67–0.86)

 

0.76 (0.66–0.88)

 

0.73 (0.63–0.85)

 
 

2006 to 2008

0.67 (0.58–0.77)

 

0.61 (0.53–0.71)

 

0.66 (0.56–0.79)

 

0.63 (0.53–0.75)

 
 

2009 to 2011

0.63 (0.53–0.76)

 

0.62 (0.51–0.75)

 

0.55 (0.44–0.69)

 

0.55 (0.44–0.70)

 

Gender

Male

Reference

<0.001

Reference

<0.001

Reference

0.001

Reference

<0.001

 

Female

0.79 (0.72–0.88)

 

0.70 (0.63–0.78)

 

0.81 (0.72–0.92)

 

0.77 (0.68–0.88)

 

Age

<50

Reference

<0.001

Reference

<0.001

Reference

<0.001

Reference

<0.001

 

50–64

1.27 (1.08–1.50)

 

1.40 (1.19–1.66)

 

1.00 (0.83–1.19)

 

1.11 (0.92–1.33)

 
 

65–79

2.25 (1.92–2.63)

 

2.64 (2.25–3.10)

 

1.54 (1.29–1.83)

 

1.83 (1.53–2.18)

 
 

80+

4.92 (4.15–5.83)

 

5.64 (4.70–6.76)

 

2.91 (2.39–3.55)

 

3.19 (2.58–3.95)

 

Ethnicity

Caucasian

Reference

0.001

Reference

0.002

Reference

0.013

Reference

0.058

 

African-American

1.19 (1.06–1.35)

 

1.22 (1.07–1.39)

 

1.15 (0.99–1.34)

 

1.08 (0.92–1.27)

 
 

Other/Unknown

0.86 (0.74–1.01)

 

0.88 (0.76–1.03)

 

0.82 (0.68–1.00)

 

0.83 (0.68–1.00)

 

Marital status

Married

Reference

<0.001

Reference

<0.001

Reference

<0.001

Reference

<0.001

 

Single

1.18 (1.03–1.36)

 

1.38 (1.19–1.59)

 

1.29 (1.10–1.53)

 

1.40 (1.18–1.66)

 
 

Other/Unknown

1.48 (1.32–1.66)

 

1.19 (1.05–1.35)

 

1.44 (1.25–1.65)

 

1.22 (1.05–1.42)

 
  1. Hazard ratios (HR) with 95 % confidence intervals
  2. aunivariate Cox regression analysis
  3. bmultivariable Cox regression analysis full model including all covariates depicted in the table rows on the left
  4. clikelihood ratio tests
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